Projects per year
Abstract
Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with pro-inflammatory, chemotactic, and growth-promoting activities. In addition, MIF has gained substantial attention as a pivotal upstream mediator of innate and adaptive immune responses and with pathologic roles in several diseases. Of less importance in mammals is an intrinsic but non-physiologic enzymatic activity that points to MIF's evolution from an ancient defense molecule. Therefore, it is not surprising that mif-like genes also have been found across a range of different organisms including bacteria, plants, protozoa, helminths, molluscs, arthropods, fish, amphibians and birds. While Genebank analysis identifying mif-like genes across species is extensive, contained herein is an overview of the non-mammalian MIF-like proteins that have been most well studied experimentally. For many of these organisms, MIF contributes to an innate defense system or plays a role in development. For parasitic organisms however, MIF appears to function as a virulence factor aiding in the establishment or persistence of infection by modulating the host immune response. Consequently, a combined targeting of both parasitic and host MIF could lead to more effective treatment strategies for parasitic diseases of socioeconomic importance.
Original language | English |
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Pages (from-to) | 858-867 |
Number of pages | 10 |
Journal | Immunobiology |
Volume | 222 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2017 |
Keywords
- Homology
- Immunity
- Macrophage migration inhibitory factor (MIF)
- Parasitology
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Dive into the research topics of 'Reprint of: The non-mammalian MIF superfamily'. Together they form a unique fingerprint.Projects
- 1 Finished
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SRP47: Strategic Research Programme: Molecular Imaging and targeting of macrophages in Inflammation (ITARMI)
Lahoutte, T., Van Ginderachter, J., Devoogdt, N. & De Jonge, J.
1/11/17 → 31/10/22
Project: Fundamental