Resolution of Protected Silaproline for a Gram Scale Preparation

Charlotte Martin, Nicolas Vanthuyne, Helene Miramon, Jean Martinez, Florine Cavelier

Research output: Contribution to journalArticlepeer-review


Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-(L) Sip-OH on the gram scale using chiral HPLC resolution.
Original languageEnglish
Pages (from-to)649–655
Number of pages6
JournalAmino Acids
Publication statusPublished - 15 Oct 2011


Dive into the research topics of 'Resolution of Protected Silaproline for a Gram Scale Preparation'. Together they form a unique fingerprint.

Cite this