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Resolving power in liquid chromatography: A trade-off between efficiency and analysis time

Research output: Contribution to journalScientific reviewpeer-review

23 Citations (Scopus)
310 Downloads (Pure)

Abstract

This review describes chromatographic dispersion and different plate-height models frequently used to assess the chromatographic performance of ultra-high-pressure liquid chromatography column technology. Furthermore, different performance indices, including the resolution, the separation impedance, and kinetic plots are discussed allowing to quantify and visualize the resolving power in liquid chromatography. The construction of kinetic plots is explained, and different visualization approaches are highlighted. Finally, key instrument and column-technology developments to advance the kinetic performance limits are discussed and selected state-of-the-art applications are highlighted.
Original languageEnglish
Pages (from-to)38-50
Number of pages13
JournalJournal of Separation Science
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • kinetic performance
  • kinetic plot
  • ultra high performance liquid chromatography
  • ultra high pressure liquid chromatography
  • van Deemter curve

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