Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study

S Holzhauer; Kristin Jochmans; Guy Kenet; R Knoefler; R Schobess; U Nowak-Gottl

Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study

S Holzhauer, Kristin Jochmans, Guy Kenet, R Knoefler, R Schobess, U Nowak-Gottl

Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research

Abstract

Background
Antithrombin (AT), protein C (PC) or Protein S (PS) deficiency states are rare thrombophilic risk factors which contribute to the early development of venous thrombosis (VTE) in adults and children. Aim of this cohort study was to (i) present the clinical and laboratory data of children with VTE and AT, PC or PS deficiency and (ii) to determine the relative and absolute risks for first symptomatic VTE in family members of children with VTE with respect to their carrier status.

Methods and results
In a multicenter cohort study we screened 206 patients (
Conclusions
The presence of AT, PC or PS deficiency increases risk of VTE in family members of pediatric index patients. IT screening of asymptomatic relatives of children with VTE and these deficiency states therefore provides a logical risk-stratification strategy in future interventional studies aimed at improving VTE prevention.

Original language	English
Title of host publication	Journal of Thrombosis and Haemostasis
Pages	591-591
Number of pages	1
Volume	91
Publication status	Published - 2011

Publication series

Name
Number	suppl2

Keywords

antithrombin
protein S
protein C

Cite this

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title = "Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study",

abstract = "Background Antithrombin (AT), protein C (PC) or Protein S (PS) deficiency states are rare thrombophilic risk factors which contribute to the early development of venous thrombosis (VTE) in adults and children. Aim of this cohort study was to (i) present the clinical and laboratory data of children with VTE and AT, PC or PS deficiency and (ii) to determine the relative and absolute risks for first symptomatic VTE in family members of children with VTE with respect to their carrier status. Methods and results In a multicenter cohort study we screened 206 patients ( Conclusions The presence of AT, PC or PS deficiency increases risk of VTE in family members of pediatric index patients. IT screening of asymptomatic relatives of children with VTE and these deficiency states therefore provides a logical risk-stratification strategy in future interventional studies aimed at improving VTE prevention.",

keywords = "antithrombin, protein S, protein C",

author = "S Holzhauer and Kristin Jochmans and Guy Kenet and R Knoefler and R Schobess and U Nowak-Gottl",

year = "2011",

language = "English",

volume = "91",

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Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study. / Holzhauer, S; Jochmans, Kristin; Kenet, Guy; Knoefler, R; Schobess, R; Nowak-Gottl, U.

Journal of Thrombosis and Haemostasis. Vol. 91 2011. p. 591-591.

Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research

TY - CHAP

T1 - Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study

AU - Holzhauer, S

AU - Jochmans, Kristin

AU - Kenet, Guy

AU - Knoefler, R

AU - Schobess, R

AU - Nowak-Gottl, U

PY - 2011

Y1 - 2011

N2 - Background Antithrombin (AT), protein C (PC) or Protein S (PS) deficiency states are rare thrombophilic risk factors which contribute to the early development of venous thrombosis (VTE) in adults and children. Aim of this cohort study was to (i) present the clinical and laboratory data of children with VTE and AT, PC or PS deficiency and (ii) to determine the relative and absolute risks for first symptomatic VTE in family members of children with VTE with respect to their carrier status. Methods and results In a multicenter cohort study we screened 206 patients ( Conclusions The presence of AT, PC or PS deficiency increases risk of VTE in family members of pediatric index patients. IT screening of asymptomatic relatives of children with VTE and these deficiency states therefore provides a logical risk-stratification strategy in future interventional studies aimed at improving VTE prevention.

AB - Background Antithrombin (AT), protein C (PC) or Protein S (PS) deficiency states are rare thrombophilic risk factors which contribute to the early development of venous thrombosis (VTE) in adults and children. Aim of this cohort study was to (i) present the clinical and laboratory data of children with VTE and AT, PC or PS deficiency and (ii) to determine the relative and absolute risks for first symptomatic VTE in family members of children with VTE with respect to their carrier status. Methods and results In a multicenter cohort study we screened 206 patients ( Conclusions The presence of AT, PC or PS deficiency increases risk of VTE in family members of pediatric index patients. IT screening of asymptomatic relatives of children with VTE and these deficiency states therefore provides a logical risk-stratification strategy in future interventional studies aimed at improving VTE prevention.

KW - antithrombin

KW - protein S

KW - protein C

M3 - Meeting abstract (Book)

VL - 91

SP - 591

EP - 591

BT - Journal of Thrombosis and Haemostasis

ER -

Role of antithrombin, protein C and protein S deficiency on incidence of symptomatic thrombosis in children and their relatives: a multicenter European cohort study

Abstract

Publication series

Keywords

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