Role of circadian rhythm disorders in EMT and tumor-immune interactions in endocrine-related cancers.

E Hadadi, H Acloque

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The circadian rhythm is a major environmental regulator of plants and animal physiology. The alternation of days and nights is translated at the cell and tissue level thanks to a molecular machinery, called the circadian clock. This clock controls in particular numerous endocrine functions, and its imbalances can have serious consequences on homeostasis. This is particularly true for the development of endocrine-related cancers, like breast, ovarian and prostate cancer. Circadian rhythm disorder (CRD) not only affects key hormone levels (including oestrogen, melatonin, insulin, glucagon, cortisol) but also favours a pro-inflammatory and immunosuppressive phenotype in the tumour microenvironment. This particular aspect is conducive to epithelial-mesenchymal transition (EMT) of solid epithelial tumours and cancer cell dissemination. It also favours resistance to chemo- and immunotherapy. Here, we discuss the current knowledge on this crosstalk between CRD, EMT and the immune microenvironment in endocrine-related cancers and its consequences for the development of efficient therapies.
Original languageEnglish
Pages (from-to)R67–R80
Number of pages14
JournalEndocrine-Related Cancer
Volume28
Issue number2
DOIs
Publication statusPublished - 28 Feb 2021

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