Objective Up to now, no data exist about Leydig cell function of pubertal boys born after Intracytoplasmic Sperm Injection (ICSI). To evaluate a potential risk of gonadal dysfunction in children born from fathers with compromised fertility, testicular function was assessed by measurement of salivary testosterone. Design Morning salivary testosterone levels at the age of 14 years were compared between 58 ICSI teenagers, who are part of the worldwide eldest ICSI cohort and 62 boys born after spontaneous conception (SC). Results Salivary testosterone levels were comparable between ICSI (113 ±42 pg/mL) and SC (123 ±56 pg/mL) teenagers at the age of 14 years. In the ICSI group, testosterone levels in boys from fathers with severe oligozoospermia were not different from concentrations in boys from fathers without severe oligozoospermia (115.5 ±43 pg/mL and 109 ±41 pg/mL, respectively). Conclusion At the age of 14 years, pubertal ICSI boys show testosterone levels comparable to their peers born after SC. ICSI adolescents fathered from men with severely compromised spermatogenesis show comparable testosterone levels to those from fathers with normal spermatogenesis. However, further follow-up of ICSI teenagers up to young adulthood is mandatory to confirm a normal gonadal function.
|Number of pages||3|
|Publication status||Published - Feb 2011|
Bibliographical noteJ. L. H. Evers
- Leydig Cells/physiology
- Prospective Studies
- Sperm Injections, Intracytoplasmic*