Second generation cryoballoon ablation for atrial fibrillation in young adults: midterm outcome in patients under 40 years of age

Darragh Moran, Valentina De Regibus, Carlo de Asmundis, Ken Takarada, Giacomo Mugnai, Erwin Ströker, Arash Aryana, Saverio Iacopino, Diego Ruggiero, Hugo Enrique Coutiño-Moreno, Rajin Choudhury, Juan-Pablo Abugattas, Ebru Hacioglu, Gaetano Paparella, Pedro Brugada, Jean-Baptiste Chierchia

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


AIMS: Pulmonary vein isolation (PVI) has been demonstrated more effective in young patients, in which the substrate for atrial fibrillation (AF) is probably more confined to pulmonary vein potentials. The present study sought to focus on the midterm outcomes in patients under 40 years having undergone PVI with the Cryoballoon Advance because of drug resistant AF.

METHODS AND RESULTS: Between June 2012 and December 2015, 57 patients having undergone Cryoballoon ablation (CB-A) below 40 years of age for AF in our centre were retrospectively analysed and considered for our analysis. All patients underwent this procedure with the 28 mm Cryoballon Advance. All 227 veins were successfully isolated without the need for additional focal tip ablation. Median follow-up was 18 ±10 months. The freedom from AF after a blanking period of 3 months was 88% in our cohort of patients younger than 40 years old. The most frequent periprocedural complication was related to the groin puncture and occurred in 2 patients. After a single procedure, the only univariate predictor of clinical recurrence was the diagnosis of hypertrophic cardiomyopathy.

CONCLUSION: Young patients affected by AF can be effectively and safely treated with CB-A that grants freedom from AF in 88% of the patients at 18 months follow-up following a 3-month blanking period. All veins could be isolated with the large 28 mm Cryoballoon Advance only.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
Issue number2
Publication statusPublished - Feb 2018


  • Ablation
  • Atrial fibrillation
  • Cryoballoon
  • Pulmonary vein isolation
  • Recurrence
  • Young patients
  • Age Factors
  • Humans
  • Risk Factors
  • Male
  • Treatment Outcome
  • Cardiac Catheters
  • Equipment Design
  • Catheter Ablation/adverse effects
  • Time Factors
  • Cryosurgery/adverse effects
  • Adult
  • Female
  • Retrospective Studies
  • Atrial Fibrillation/diagnosis
  • Pulmonary Veins/physiopathology


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