Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Elahe Naghdi; Ali Reza Fakhari; Martyna Baca; Wim De Malsche

doi:10.1016/j.chroma.2019.460752

Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Elahe Naghdi, Ali Reza Fakhari, Martyna Baca, Wim De Malsche

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

104 Downloads (Pure)

Abstract

The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) as the chiral selector. Analyte mixtures composed of non-steroidal anti-inflammatory drugs were tested to reveal the enantioseparation potential of the column. The mechanism of chiral discrimination was investigated. The adsorbed Hp-beta-CDs on the column surface experience different interaction with enantiomers. The chiral stationary phase showed satisfying stability and could be easily restored by recovering the selector with sufficient flushing and repeating the loading procedure. The peak capacity of the column was evaluated, and it was found high enough to separate three enantiomer couples using a one-dimensional LC technique. (C) 2019 Elsevier B.V. All rights reserved.

Original language	English
Article number	460752
Journal	Journal of Chromatography A
Volume	1615
DOIs	https://doi.org/10.1016/j.chroma.2019.460752
Publication status	Published - 29 Mar 2020

Bibliographical note

Funding Information:
The authors gratefully acknowledge support from Vrije Universiteit Brussel and Shahid Beheshti University.

Publisher Copyright:
© 2019 Elsevier B.V.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Chiral
Dynamic coating
One-dimensional liquid chromatography
Non-steroidal anti-inflammatory drugs
Porous silicon pillar array column

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10.1016/j.chroma.2019.460752

MS
The author(s) opt to apply XI.196. § 2/1 book 1 “intellectuele eigendommen” of the Belgian Federal Code of Economic Law in order to obey funder requirements.
Accepted author manuscript, 441 KB

Cite this

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title = "Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column",

abstract = "The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) as the chiral selector. Analyte mixtures composed of non-steroidal anti-inflammatory drugs were tested to reveal the enantioseparation potential of the column. The mechanism of chiral discrimination was investigated. The adsorbed Hp-beta-CDs on the column surface experience different interaction with enantiomers. The chiral stationary phase showed satisfying stability and could be easily restored by recovering the selector with sufficient flushing and repeating the loading procedure. The peak capacity of the column was evaluated, and it was found high enough to separate three enantiomer couples using a one-dimensional LC technique. (C) 2019 Elsevier B.V. All rights reserved.",

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author = "Elahe Naghdi and Fakhari, {Ali Reza} and Martyna Baca and {De Malsche}, Wim",

note = "Funding Information: The authors gratefully acknowledge support from Vrije Universiteit Brussel and Shahid Beheshti University. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = mar,

day = "29",

doi = "10.1016/j.chroma.2019.460752",

language = "English",

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journal = "Journal of Chromatography. A",

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Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column. / Naghdi, Elahe; Fakhari, Ali Reza; Baca, Martyna; De Malsche, Wim.

In: Journal of Chromatography A, Vol. 1615, 460752, 29.03.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

AU - Naghdi, Elahe

AU - Fakhari, Ali Reza

AU - Baca, Martyna

AU - De Malsche, Wim

N1 - Funding Information: The authors gratefully acknowledge support from Vrije Universiteit Brussel and Shahid Beheshti University. Publisher Copyright: © 2019 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/3/29

Y1 - 2020/3/29

N2 - The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) as the chiral selector. Analyte mixtures composed of non-steroidal anti-inflammatory drugs were tested to reveal the enantioseparation potential of the column. The mechanism of chiral discrimination was investigated. The adsorbed Hp-beta-CDs on the column surface experience different interaction with enantiomers. The chiral stationary phase showed satisfying stability and could be easily restored by recovering the selector with sufficient flushing and repeating the loading procedure. The peak capacity of the column was evaluated, and it was found high enough to separate three enantiomer couples using a one-dimensional LC technique. (C) 2019 Elsevier B.V. All rights reserved.

AB - The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) as the chiral selector. Analyte mixtures composed of non-steroidal anti-inflammatory drugs were tested to reveal the enantioseparation potential of the column. The mechanism of chiral discrimination was investigated. The adsorbed Hp-beta-CDs on the column surface experience different interaction with enantiomers. The chiral stationary phase showed satisfying stability and could be easily restored by recovering the selector with sufficient flushing and repeating the loading procedure. The peak capacity of the column was evaluated, and it was found high enough to separate three enantiomer couples using a one-dimensional LC technique. (C) 2019 Elsevier B.V. All rights reserved.

KW - Chiral

KW - Dynamic coating

KW - One-dimensional liquid chromatography

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KW - Porous silicon pillar array column

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Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Abstract

Bibliographical note

Keywords

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SRP51: SRP-Onderzoekszwaartepunt: Optical and microfluidic tools to unravel the dynamics of bio-condensates

EU502: Exploiting vortices to suppress dispersion and reach new separation power boundaries (EVODIS)

Cite this

Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Projects

SRP51: SRP-Onderzoekszwaartepunt: Optical and microfluidic tools to unravel the dynamics of bio-condensates

EU502: Exploiting vortices to suppress dispersion and reach new separation power boundaries (EVODIS)

Cite this