Smads and chromatin modulation.

Leonardus Van Grunsven, G Verstappen, Danny Huylebroeck, Kristin Verschueren

Research output: Contribution to journalArticle

23 Citations (Scopus)


Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type beta (TGFbeta) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFbeta signaling.
Original languageEnglish
Pages (from-to)495-512
Number of pages18
JournalCytokine & Growth Factor Reviews
Issue number16
Publication statusPublished - 2005


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