TY - JOUR
T1 - Socio-economic outcomes among long-term childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC CLG studies
T2 - Results of the 58LAE study
AU - European Organisation for Research and Treatment of Cancer (EORTC) Children's Leukemia Group (CLG)
AU - Barbati, Melissa
AU - Kicinski, Michal
AU - Suciu, Stefan
AU - Mazingue, Françoise
AU - Vandecruys, Els
AU - Plat, Geneviève
AU - Uyttebroeck, Anne
AU - Paillard, Catherine
AU - Dresse, Marie-Françoise
AU - Simon, Pauline
AU - Pluchart, Claire
AU - Minckes, Odile
AU - Ferster, Alina
AU - Freycon, Claire
AU - Millot, Frederic
AU - Van Der Werff Ten Bosch, Jutte
AU - Chantrain, Christophe
AU - Paulus, Robert
AU - de Schaetzen, Gaetan
AU - Rossi, Giovanna
AU - Rohrlich, Pierre
AU - Benoit, Yves
AU - Piette, Caroline
N1 - © 2022 The Authors. European Journal of Cancer Care published by John Wiley & Sons Ltd.
PY - 2022/11
Y1 - 2022/11
N2 - OBJECTIVE: The objective of this study is to evaluate the socio-economic outcomes of survivors of childhood acute lymphoblastic leukaemia (ALL).METHODS: Childhood ALL adult survivors, enrolled in EORTC trials between 1971 and 1998 in France and Belgium, were invited to fill out a questionnaire with information about their socio-economic situation (living with a partner, having a university degree, having a job, working part time and history of having a paid job). The outcomes were compared with two matched control populations.RESULTS: Among 1418 eligible patients, 507 (35.8%) participated, including 39 (8%) and 61 (12%) patients who received a haematopoietic stem cell transplantation (HSCT) and a cranial radiotherapy (CRT), respectively. The median time to follow-up was 20 years, and median age was 25 years. Survivors showed a socio-economic level at least as good as controls. HCST and CRT were associated with a higher probability of not obtaining a bachelor degree (respectively OR = 3.49, 95% CI: 1.46-8.35 and OR = 2.31, 95% CI: 1.04-5.15), HSCT was associated with unemployment (OR = 2.89, 95% CI: 1.09-7.65) and having a relapse was associated with a higher probability of not having a partner (OR = 1.88, 95% CI: 1.01-3.51) adjusting for confounders.CONCLUSION: Childhood ALL survivors showed a high level of socio-economic participation. HCST and CRT were associated with poorer functioning.
AB - OBJECTIVE: The objective of this study is to evaluate the socio-economic outcomes of survivors of childhood acute lymphoblastic leukaemia (ALL).METHODS: Childhood ALL adult survivors, enrolled in EORTC trials between 1971 and 1998 in France and Belgium, were invited to fill out a questionnaire with information about their socio-economic situation (living with a partner, having a university degree, having a job, working part time and history of having a paid job). The outcomes were compared with two matched control populations.RESULTS: Among 1418 eligible patients, 507 (35.8%) participated, including 39 (8%) and 61 (12%) patients who received a haematopoietic stem cell transplantation (HSCT) and a cranial radiotherapy (CRT), respectively. The median time to follow-up was 20 years, and median age was 25 years. Survivors showed a socio-economic level at least as good as controls. HCST and CRT were associated with a higher probability of not obtaining a bachelor degree (respectively OR = 3.49, 95% CI: 1.46-8.35 and OR = 2.31, 95% CI: 1.04-5.15), HSCT was associated with unemployment (OR = 2.89, 95% CI: 1.09-7.65) and having a relapse was associated with a higher probability of not having a partner (OR = 1.88, 95% CI: 1.01-3.51) adjusting for confounders.CONCLUSION: Childhood ALL survivors showed a high level of socio-economic participation. HCST and CRT were associated with poorer functioning.
KW - Adult
KW - Humans
KW - Survivors
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
KW - Cranial Irradiation
KW - Employment
KW - Marital Status
UR - http://www.scopus.com/inward/record.url?scp=85140378158&partnerID=8YFLogxK
U2 - 10.1111/ecc.13755
DO - 10.1111/ecc.13755
M3 - Article
C2 - 36284405
VL - 31
JO - European Journal of Cancer Care
JF - European Journal of Cancer Care
SN - 0961-5423
IS - 6
M1 - e13755
ER -