Solitary Clear Cell Renal Cell Carcinoma Metastasis to the Eyelid: A Case Report

Ognjen Zrinšćak, Armin Kasumović, Iva Krolo, Renata Ivekovic, Maja Malenica Ravlić, Igor Tomašković, Zoran Vatavuk

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: This study is a case of solitary clear cell renal cell carcinoma (ccRCC) eyelid metastasis in a 66-year-old man as the first sign of a primary tumor. ccRCC usually spreads to the lungs, mediastinum, bones, liver, and brain, while ocular metastases are rare.

CASE PRESENTATION: Solitary metastasis presented as a solid mass in the central third of the upper eyelid, which has been growing for 3 weeks. Treatment included tumor removal and blepharoplasty. Histopathological examination showed metastasis of clear cell renal carcinoma. A thorough examination revealed a primary tumor on the lower pole of the right kidney. A right nephrectomy was performed, and histopathology showed ccRCC. Postoperative examinations showed no signs of local or systemic disease. Sunitinib malate was administered to the patient.

CONCLUSION: The eyelid metastasis in this case was still solitary and had been discovered before the existence of the primary tumor was known. Ocular metastasis of renal carcinoma is a rare initial manifestation of the disease and therefore requires a multidisciplinary approach in the treatment of these patients.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalCase Reports in Oncology
Issue number1
Publication statusPublished - 2024

Bibliographical note

© 2024 The Author(s). Published by S. Karger AG, Basel.


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