Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β

Timo De Groof; Yoline Lauwers; Tessa De Pauw; Mohit Saxena; Cécile Vincke; Jolien Van Craenenbroeck; Catherine Chapon; Roger Le Grand; Geert Raes; Thibaut Naninck; Jo Van Ginderachter; Nick Devoogdt

doi:10.1007/s00259-024-06896-3

Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β

Timo De Groof, Yoline Lauwers, Tessa De Pauw, Mohit Saxena, Cécile Vincke, Jolien Van Craenenbroeck, Catherine Chapon, Roger Le Grand, Geert Raes, Thibaut Naninck, Jo Van Ginderachter, Nick Devoogdt

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8+ T-cell dynamics.

Original language	English
Pages (from-to)	193-207
Number of pages	15
Journal	Eur J Nucl Med Mol Imaging
Volume	52
DOIs	https://doi.org/10.1007/s00259-024-06896-3
Publication status	Published - 2 Sep 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

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10.1007/s00259-024-06896-3

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De Groof, Timo ; Lauwers, Yoline ; Pauw, Tessa De ; Saxena, Mohit ; Vincke, Cécile ; Craenenbroeck, Jolien Van ; Chapon, Catherine ; Grand, Roger Le ; Raes, Geert ; Naninck, Thibaut ; Van Ginderachter, Jo ; Devoogdt, Nick. / Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β. In: Eur J Nucl Med Mol Imaging. 2024 ; Vol. 52. pp. 193-207.

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title = "Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β",

abstract = "While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8+ T-cell dynamics.",

author = "{De Groof}, Timo and Yoline Lauwers and Pauw, {Tessa De} and Mohit Saxena and C{\'e}cile Vincke and Craenenbroeck, {Jolien Van} and Catherine Chapon and Grand, {Roger Le} and Geert Raes and Thibaut Naninck and {Van Ginderachter}, Jo and Nick Devoogdt",

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day = "2",

doi = "10.1007/s00259-024-06896-3",

language = "English",

volume = "52",

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Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β. / De Groof, Timo ; Lauwers, Yoline ; Pauw, Tessa De; Saxena, Mohit; Vincke, Cécile ; Craenenbroeck, Jolien Van; Chapon, Catherine; Grand, Roger Le; Raes, Geert; Naninck, Thibaut; Van Ginderachter, Jo ; Devoogdt, Nick.

In: Eur J Nucl Med Mol Imaging, Vol. 52, 02.09.2024, p. 193-207.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β

AU - De Groof, Timo

AU - Lauwers, Yoline

AU - Pauw, Tessa De

AU - Saxena, Mohit

AU - Vincke, Cécile

AU - Craenenbroeck, Jolien Van

AU - Chapon, Catherine

AU - Grand, Roger Le

AU - Raes, Geert

AU - Naninck, Thibaut

AU - Van Ginderachter, Jo

AU - Devoogdt, Nick

PY - 2024/9/2

Y1 - 2024/9/2

N2 - While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8+ T-cell dynamics.

AB - While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8+ T-cell dynamics.

UR - https://doi.org/10.21203/rs.3.rs-4322357/v1

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DO - 10.1007/s00259-024-06896-3

M3 - Article

C2 - 39218831

VL - 52

SP - 193

EP - 207

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

ER -

Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β

Abstract

Bibliographical note

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SRP83: SRP-Onderzoekszwaartepunt: ITAREG: Molecular Imaging and TArgeting of immunoREGulatory cells in Inflammatory diseases and cancer

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Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8β

Abstract

Bibliographical note

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Projects

SRP83: SRP-Onderzoekszwaartepunt: ITAREG: Molecular Imaging and TArgeting of immunoREGulatory cells in Inflammatory diseases and cancer

Cite this