Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

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• Active

  SRP95: Exploiting Peptides as Protein Binders, Modulators, Inhibitors and Biomaterials for Imaging and Therapy [Exploit-PeptIT]

  Ballet, S., Caveliers, V., Hernot, S., Versées, W., Devoogdt, N., Covens, P. & Martin, C.

  1/03/24 → 28/02/29

  Project: Fundamental

  • Single-Domain Antibodies 100%
  • Peptides 92%
  • Parkinson Disease Associated Proteins 89%
  • neuropeptide FF receptor 87%
  • Peptide 74%

• FWOAL1054: Understanding the structure, function and mechanism of Synaptojanin1 in the context of neurological disease

  Versées, W.

  1/01/22 → 31/12/25

  Project: Fundamental

  • synaptojanin 100%
  • Single-Domain Antibodies 42%
  • 2-acylglycerophosphate acyltransferase 41%
  • GTP Phosphohydrolases 32%
  • Autophagy 31%
• Finished

  FWOAL901: Unravelling and modulating the complex conformational cycle of the Roco protein family

  Versées, W.

  1/01/19 → 31/12/22

  Project: Fundamental

  • Leucine 100%
  • GTP Phosphohydrolases 89%
  • Single-Domain Antibodies 83%
  • Phosphotransferases 71%
  • Parkinson Disease 39%