Structure, function, and mechanism of thioredoxin proteins

Jean François Collet, Joris Messens

Research output: Contribution to journalArticlepeer-review

308 Citations (Scopus)


Thioredoxins are ubiquitous antioxidant enzymes that play important roles in many health-related cellular processes. As such, the fundamental knowledge of how these enzymes work is of prime importance for understanding cellular redox mechanisms and for laying the ground for the development of future therapeutic approaches. Over the past 40 years, a really impressive amount of data has been published on thioredoxins. Here, we review the most significant results that have contributed to our knowledge regarding the structure, the function, and the mechanism of these crucial enzymes.
Original languageEnglish
Pages (from-to)1205-1216
Number of pages12
JournalAntioxid Redox Signal
Issue number8
Publication statusPublished - Oct 2010


  • thioredoxin
  • structure/function
  • antioxidant


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