Structure, regulation and function of gap junctions in liver

Joost Willebrords; Sara Crespo Yanguas; Michaël Maes; Elke Decrock; Nan Wang; Luc Leybaert; Tereza Cristina da Silva; Isabel Veloso Alves Pereira; Hartmut Jaeschke; Bruno Cogliati; Mathieu Vinken

doi:10.3109/15419061.2016.1151875

Structure, regulation and function of gap junctions in liver

Joost Willebrords, Sara Crespo Yanguas, Michaël Maes, Elke Decrock, Nan Wang, Luc Leybaert, Tereza Cristina da Silva, Isabel Veloso Alves Pereira, Hartmut Jaeschke, Bruno Cogliati, Mathieu Vinken

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to posttranslational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Cell Communication and Adhesion
Volume	22
Issue number	2-6
DOIs	https://doi.org/10.3109/15419061.2016.1151875
Publication status	Published - 13 Sep 2015

Keywords

gap junctions
Liver
Connexin

Access to Document

10.3109/15419061.2016.1151875

1 Active
5 Finished

OZR2651: International Joint Research Group - Liver Connexin and Pannexin Research Group (LCPR)
Vinken, M., Rogiers, V., Cogliati, B. & Dagli, M. L.
1/08/14 → 1/07/26
Project: Fundamental
OZR2814: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject - Bench fee voor Joint PhD, VUB-Universidade de Sao Paulo, Sara Crespo Yanguas
Vinken, M.
10/06/15 → 31/07/17
Project: Fundamental
OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes
Vinken, M.
10/06/15 → 31/07/17
Project: Fundamental

24 Citations
1 Article

Connexins and pannexins in liver damage
Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Alves Pereira, I. V., Cogliati, B., Zaidan Dagli, M. L. & Vinken, M., 18 Feb 2016, In: EXCLI Journal. 15, p. 177-186 10 p.
Research output: Contribution to journal › Article › peer-review

1 Talk or presentation at a workshop/seminar

The role of connexins, pannexins and their channels in liver fibrosis
Sara Crespo Yanguas (Speaker)
28 Nov 2018
Activity: Talk or presentation › Talk or presentation at a workshop/seminar

Cite this

@article{8f1282ef8f264af9a34e0bc7f0c696c5,

title = "Structure, regulation and function of gap junctions in liver",

abstract = "Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to posttranslational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.",

keywords = "gap junctions, Liver, Connexin",

author = "Joost Willebrords and {Crespo Yanguas}, Sara and Micha{\"e}l Maes and Elke Decrock and Nan Wang and Luc Leybaert and {da Silva}, {Tereza Cristina} and {Alves Pereira}, {Isabel Veloso} and Hartmut Jaeschke and Bruno Cogliati and Mathieu Vinken",

year = "2015",

month = sep,

day = "13",

doi = "10.3109/15419061.2016.1151875",

language = "English",

volume = "22",

pages = "29--37",

journal = "Cell Communication and Adhesion",

issn = "1541-9061",

publisher = "Informa Healthcare",

number = "2-6",

}

Structure, regulation and function of gap junctions in liver. / Willebrords, Joost; Crespo Yanguas, Sara; Maes, Michaël; Decrock, Elke; Wang, Nan; Leybaert, Luc; da Silva, Tereza Cristina; Alves Pereira, Isabel Veloso; Jaeschke, Hartmut; Cogliati, Bruno; Vinken, Mathieu.

In: Cell Communication and Adhesion, Vol. 22, No. 2-6, 13.09.2015, p. 29-37.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Structure, regulation and function of gap junctions in liver

AU - Willebrords, Joost

AU - Crespo Yanguas, Sara

AU - Maes, Michaël

AU - Decrock, Elke

AU - Wang, Nan

AU - Leybaert, Luc

AU - da Silva, Tereza Cristina

AU - Alves Pereira, Isabel Veloso

AU - Jaeschke, Hartmut

AU - Cogliati, Bruno

AU - Vinken, Mathieu

PY - 2015/9/13

Y1 - 2015/9/13

N2 - Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to posttranslational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.

AB - Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to posttranslational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.

KW - gap junctions

KW - Liver

KW - Connexin

U2 - 10.3109/15419061.2016.1151875

DO - 10.3109/15419061.2016.1151875

M3 - Article

VL - 22

SP - 29

EP - 37

JO - Cell Communication and Adhesion

JF - Cell Communication and Adhesion

SN - 1541-9061

IS - 2-6

ER -

Structure, regulation and function of gap junctions in liver

Abstract

Keywords

Access to Document

Fingerprint

Projects

OZR2651: International Joint Research Group - Liver Connexin and Pannexin Research Group (LCPR)

OZR2814: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject - Bench fee voor Joint PhD, VUB-Universidade de Sao Paulo, Sara Crespo Yanguas

OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes

Research output

Connexins and pannexins in liver damage

Activities

The role of connexins, pannexins and their channels in liver fibrosis

Cite this