Synthesis of gem-difluorinated 1,6-naphthyridin-5,7-diones

Karel Piron; Sara Kenis; Guido Verniest; Riccardo Surmont; Jan Willem Thuring; Peter Ten Holte; Frederik Deroose; Norbert De Kimpe

Synthesis of gem-difluorinated 1,6-naphthyridin-5,7-diones

Karel Piron, Sara Kenis, Guido Verniest, Riccardo Surmont, Jan Willem Thuring, Peter Ten Holte, Frederik Deroose, Norbert De Kimpe

Department of Bio-engineering Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.

Original language	English
Pages (from-to)	6941-6947
Number of pages	7
Journal	Tetrahedron
Volume	68
Publication status	Published - 26 Aug 2012

Keywords

organofluorine chemistry
heterocycles

Access to Document

http://www.sciencedirect.com/science/article/pii/S0040402012008526

Ghent University (External organisation)
Guido Verniest (Member)
1 Oct 2010 → …
Activity: Membership › Membership of external research organisation

Cite this

@article{2e3c5158774b407fac92d15f0babadc2,

title = "Synthesis of gem-difluorinated 1,6-naphthyridin-5,7-diones",

abstract = "A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.",

keywords = "organofluorine chemistry, heterocycles",

author = "Karel Piron and Sara Kenis and Guido Verniest and Riccardo Surmont and Thuring, {Jan Willem} and {Ten Holte}, Peter and Frederik Deroose and {De Kimpe}, Norbert",

year = "2012",

month = aug,

day = "26",

language = "English",

volume = "68",

pages = "6941--6947",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Synthesis of gem-difluorinated 1,6-naphthyridin-5,7-diones

AU - Piron, Karel

AU - Kenis, Sara

AU - Verniest, Guido

AU - Surmont, Riccardo

AU - Thuring, Jan Willem

AU - Ten Holte, Peter

AU - Deroose, Frederik

AU - De Kimpe, Norbert

PY - 2012/8/26

Y1 - 2012/8/26

N2 - A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.

AB - A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.

KW - organofluorine chemistry

KW - heterocycles

M3 - Article

VL - 68

SP - 6941

EP - 6947

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

ER -

Synthesis of gem-difluorinated 1,6-naphthyridin-5,7-diones

Abstract

Keywords

Access to Document

Fingerprint

Activities

Ghent University (External organisation)

Cite this