System XC- as a novel modulator of corticostriatal neurotransmission

Eduard Mihai Bentea, Cynthia Moore, Agnès Villers, Madeline J Churchill, Rebecca Hood, Lauren Deneyer, Lise Verbruggen, Giulia Albertini, Hideyo Sato, Laurence Ris, Charles Meshul, Ann Massie

Research output: Contribution to journalMeeting abstract (Journal)

4 Citations (Scopus)


System xc- is a plasma membrane amino acid antiporter, of mainly glial origin, that couples the import of cystine with the export of glutamate. System xc- (specific subunit xCT) contributes substantially to ambient extracellular glutamate levels in various regions of the brain, including the striatum and hippocampus. Despite the fact that system xc- is highly expressed in the brain and is a proposed therapeutic target for various neurological disorders, its function under physiological conditions in the central nervous system remains poorly understood. By acting as a source of glial extrasynaptic glutamate, system xc- might modulate synaptic transmission as a mechanism of neuro-glial communication. Previous electrophysiological findings indicate that system xc- delivered glutamate can inhibit excitatory synaptic neurotransmission in the corticoaccumbens pathway and at hippocampal CA3-CA1 synapses. To gain further insight into the proposed function of system xc- as modulator of synaptic transmission we here focus on corticostriatal synapses.
Original languageEnglish
Pages (from-to)S20
Number of pages1
JournalSchizophrenia Bulletin
Issue numberSupplement 1
Publication statusPublished - Apr 2018
EventSixth biennial Schizophrenia International Research Society Conference - Firenze Fiera Congress Center, Florence, Italy
Duration: 4 Apr 20188 Apr 2018
Conference number: 12.3


  • System xc-
  • neurotransmission


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