Systematic review and meta-analysis of local resection or transanal endoscopic microsurgery versus radical resection in stage i rectal cancer: A real standard?

Geneviève Veereman, Joan Vlayen, Jo Robays, Nicolas Fairon, Sabine Stordeur, Christian Rolfo, Didier Bielen, Alain Bols, Pieter Demetter, André D'hoore, Karin Haustermans, Alain Hendlisz, Arnaud Lemmers, Daniel Leonard, Freddy Penninckx, Eric Van Cutsem, Marc Peeters

Research output: Contribution to journalScientific reviewpeer-review

27 Citations (Scopus)

Abstract

Current guidelines recommend radical resection for stage I rectal cancer. However, since screening programs are being installed, an increasing number of cancers are being detected in early stages. Endoscopic resection is often performed at the time of diagnosis. This systematic review was undertaken to review the evidence on endoscopic approach vs. radical resection for stage I rectal cancer. Recommendations were issued based on the GRADE methodology and risk stratification used in clinical practice. A systematic search (until March 2015) identified 2 meta-analyses and 1 additional randomized trial. For the primary outcomes (overall survival, disease-free survival, local recurrence-free survival and metastasis-free survival) no evidence could be found on the superiority of local or radical resection. Secondary outcomes (blood loss, hospital stay, operative time, number of permanent stomas and perioperative deaths) were in favour of local resection. The authors strongly recommend radical resection for T2 rectal cancer, but consider 'en bloc' local resection sufficient for pT1 sm1 rectal cancers when confirmed pathologically. Discussion by a multidisciplinary team and adequate surveillance remain mandatory.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Volume114
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Humans
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Rectal Neoplasms
  • Transanal Endoscopic Microsurgery
  • Treatment Outcome
  • Journal Article
  • Meta-Analysis
  • Review

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