Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies

Evangelia Bolli, Maximilian Scherger, Sana Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo Van Ginderachter, Lutz Nuhn

Research output: Contribution to journalArticle

3 Citations (Scopus)
42 Downloads (Pure)

Abstract

Tumor-associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll-like receptor 7/8 agonist imidazoquinoline IMDQ is site-specifically and quantitatively coupled to single chain antibody fragments, so-called nanobodies, targeting the macrophage mannose receptor (MMR) on TAMs. Intravenous injection of these conjugates result in a tumor- and cell-specific delivery of IMDQ into MMRhigh TAMs, causing a significant decline in tumor growth. This is accompanied by a repolarization of TAMs towards a pro-inflammatory phenotype and an increase in anti-tumor T cell responses. Therefore, the therapeutic benefit of such nanobody-drug conjugates may pave the road towards effective macrophage re-educating cancer immunotherapies.
Original languageEnglish
Article number2004574
Number of pages12
JournalAdvanced Science
Volume8
Issue number10
DOIs
Publication statusPublished - 19 May 2021

Fingerprint

Dive into the research topics of 'Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies'. Together they form a unique fingerprint.

Cite this