Targeting cell-intrinsic and cell-extrinsic mechanisms of intravasation in invasive breast cancer

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Abstract

The survival of breast cancer patients with metastatic disease has not markedly improved over recent decades, highlighting the need to better understand this process. In this issue of Science Signaling, Pignatelli et al. used freshly obtained invasive ductal carcinoma cells from patients to demonstrate the need for high abundance of the invasive isoform of the Mena protein (MenaINV) in cancer cells and colony-stimulating factor 1 (CSF-1)-mediated paracrine signaling in macrophages for efficient transendothelial migration and metastasis formation in all clinical breast cancer subtypes. Furthermore, the triple negative and HER2+ subtypes, but not the ERPR+/HER2- subtype, had high CSF-1 receptor (CSF-1R) abundance and also partially used autocrine CSF-1/CSF-1R signaling for invasion. These data establish MenaINV, CSF-1/CSF-1R, and macrophages as potential therapeutic targets for most human breast cancers.
Original languageEnglish
Pages (from-to)28
Number of pages1
JournalSci. Signal
Volume7
DOIs
Publication statusPublished - 25 Nov 2014

Keywords

  • Invasive breast cancer
  • Mena protein
  • CSF-1
  • CSF-1R
  • Macrophages

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