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Abstract
Research question: Which early-diagnosed Klinefelter syndrome patients have been offered cryopreservation of testicular tissue as part of fertility preservation before spermatogonial stem cell (SSC) loss? Do these Klinefelter syndrome patients present with behavioural, cognitive and/or psychological problems? Does a testicular biopsy procedure have long-term effects on the gonadal development of Klinefelter syndrome patients? Design: Early-diagnosed Klinefelter syndrome patients followed between 2009 and 2020 and offered testicular tissue banking in an experimental context at the Universitair Ziekenhuis Brussel were included. The prevalence of behavioural, cognitive and/or psychological problems was determined. Changes in testicular volume and in gonadal function (LH, FSH, testosterone and inhibin B [INHB]) were studied. Results: Of the 48 Klinefelter syndrome patients included, 22 had testicular tissue removed (biopsy group) and 26 had no surgical intervention (control group). The need for specialized education was significantly higher in prenatally (P = 0.0159) and prepubertally (P = 0.0002) diagnosed Klinefelter syndrome patients. Psychological problems were significantly more prevalent in Klinefelter syndrome patients who did not opt for fertility preservation (P = 0.0447). In the first 4.2 (1.9–9.1) years after testicular biopsy, no difference in testicular volume was observed between the biopsied and the contralateral non-biopsied testes (P > 0.9999). After pubertal onset, no differences in LH, FSH, testosterone and INHB were found between the biopsy and the control groups (P = 0.1324 for LH, P > 0.9999 for FSH, P = 0.5433 for testosterone, P > 0.9999 for INHB). Conclusion: Early-diagnosed Klinefelter syndrome patients presented with behavioural, cognitive and/or psychological problems. Only psychological problems seemed to influence the decision towards fertility preservation. Follow-up data confirm that harvesting testicular tissue does not have a long-term impact on the gonadal development of Klinefelter syndrome patients.
Original language | English |
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Pages (from-to) | 889-895 |
Number of pages | 7 |
Journal | Reproductive BioMedicine Online |
Volume | 44 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2022 |
Bibliographical note
Funding Information:The authors are thankful to the Klinefelter Clinic of the UZ Brussel, E Van Moer (study nurse at the UZ Brussel fertility clinic) and M De Henau (medicine student at the VUB) for their help with data collection. This retrospective cohort study was supported by the Vrije Universiteit Brussel and Wetenschappelijk Fonds Willy Gepts of the UZ Brussel. The funding organizations had no role in the study conception and design, data collection, statistical analysis and interpretation of the results, supervision of the research and validation of the results, preparation, review or approval of the manuscript or the decision to submit the manuscript for publication.
Funding Information:
This retrospective cohort study was supported by the Vrije Universiteit Brussel and Wetenschappelijk Fonds Willy Gepts of the UZ Brussel. The funding organizations had no role in the study conception and design, data collection, statistical analysis and interpretation of the results, supervision of the research and validation of the results, preparation, review or approval of the manuscript or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2022 Reproductive Healthcare Ltd.
Keywords
- Fertility preservation
- Gonadal development
- Klinefelter syndrome
- Retrospective cohort study
- Testicular biopsy
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- 2 Finished
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FWOAL891: Fertility preservation in boys treated for cancer: what is the effect of harvesting testicular tissue in childhood on their later pubertal development and fertility?
Goossens, E., Van Der Werff Ten Bosch, J., Gies, I. & Tournaye, H.
1/01/18 → 31/12/19
Project: Fundamental