Test–retest reliability of left and right ventricular systolic function by new and conventional echocardiographic and cardiac magnetic resonance parameters

Laura Houard, Kaoru Tanaka, Sebastian Militaru, Agnès Pasquet, David Vancraeynest, Jean-Louis Vanoverschelde, Anne Catherine Pouleur, Bernhard L. Gerber

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims Reproducible evaluation of left (LV) and right ventricular (RV) function is crucial for clinical decision-making and
risk stratification. We evaluated whether speckle-tracking echocardiography (STE) and cardiac magnetic resonance
feature-tracking (cMR-FT) global longitudinal (GLS) and circumferential strains allow better test–retest reproducibility
of LV and RV systolic function than conventional cMR and echocardiographic parameters.
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Methods
and results
Thirty healthy volunteers and 20 chronic heart failure patients underwent cMR and STE twice on separate days to
evaluate test–retest coefficient of variation (CV), intraclass correlation coefficient (ICC) and estimated sample sizes
for significant changes in LV and RV function. Among LV parameters, cMR-left ventricular ejection fraction (LVEF)
had the highest reproducibility (CV = 6.7%, ICC = 0.98), significantly better than cMR-FT-GLS (CV = 15.1%,
ICC = 0.84), global circumferential strains (CV = 11.5%, ICC = 0.94) and echocardiographic LVEF (CV = 11.3%,
ICC = 0.93). STE-LV-GLS (CV = 8.9%, ICC = 0.94) had significantly better reproducibility than cMR-FT-LV-GLS.
Among RV parameters, STE-RV-GLS (CV = 7.3%, ICC = 0.93) had significantly better CV than cMR-right ventricular
ejection fraction (RVEF) (CV = 13%, ICC = 0.82). cMR-FT-RV-GLS (CV = 43%, ICC = 0.39) performed poorly with
significantly lower reproducibility than all other RV parameters. Owing to their superior interstudy reproducibility,
cMR-LVEF (n = 12), cMR-RVEF (n = 41), STE-LV-GLS and STE-RV-GLS (both n = 14) were the parameters allowing
the lowest calculated sample sizes to detect 10% change in LV or RV systolic function.
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Conclusion STE-LV-GLS and STE-RV-GLS showed higher test–retest reliability than other echocardiographic measurements of
LV and RV function. They also allowed smaller calculated sample sizes, supporting the use of STE-LV and RV-GLS
for longitudinal follow-up of LV and RV function.
Original languageEnglish
Pages (from-to)1157-1167
Number of pages11
JournalEuropean Heart Journal - Cardiovascular Imaging
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2021

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