Abstract
Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons.
| Original language | English |
|---|---|
| Pages (from-to) | 308-310 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 528 |
| Publication status | Published - 1 Oct 1990 |
Keywords
- Adult
- Aged
- 80 and over
- Aging/*metabolism
- Female
- Frontal Lobe/*metabolism
- Human
- Male
- Middle Age
- Receptors
- Dopamine/*metabolism
- Dopamine D1
- Tritium/diagnostic use