The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.

Research output: Unpublished contribution to conferencePoster

Abstract

Introduction Behavioural graded activity (BGA) has gained acceptance in the field and appears foremost in psychological informed practices (PIP)[1]. However, no review has been published about the effect of BGA in cancer. Therefore, this systematic review with meta-analyses determined the effectiveness of PIP with BGA compared to (1)waitlists (WLC), (2)other interventions (OI), (3)PIP-, or (4)BGA alone in cancer patients and survivors (CPaS). Methods Three databases were screened for randomized controlled trials encompassing PIP with BGA in CPaS. Effect sizes of physical activity (PA), quality of life (QoL) and debilitating symptoms were inventoried. Subgroup analyses were undertaken to reduce heterogeneity(I2>50%). Results Thirty-three studies were included, comprising 4,330 participants. Significant effects of PIP+BGA comparing to WLC were found for anxiety(SMD:-1.29[-1.71;-0.86],I2=0%), fatigue(SMD:-0.86[-1.18;-0.54],I2=61%), depression(SMD:-0.79[-1.10;-0.48],I2=0%), functional impairment(SMD:-0.72[-0.95;-0.50],I2=0%), psychological distress(SMD:-0.58[-0.82;-0.34],I2=51%), PA(SMD:-0.58[-0.84;-0.32],I2=47% and SMD:-0.51[-0.90;-0.13],I2=0%), QoL(SMD:-0.38[-0.68;-0.09],I2=51%), social impairment(SMD:-0.33[-0.58;-0.08],I2=0%) and only the psychological distress(SMD:-0.89[-1.76;-0.02],I2=82%) remained significantly after 1-to 3-months. When comparing PIP+BGA to OI, significant effects were found for anxiety(SMD:-0.47[-0.88;-0.06],I2=83%), depression(SMD:-0.46[-0.84;-0.09],I2=82%), fatigue(SMD:-0.35[-0.51;-0.20],I2=48%), and PA(SMD:-0.26[-0.41;-0.11],I2=44%). After 1-to 3-months, anxiety(SMD:-1.54[-2.88;-0.21],I2=87%), depression(SMD:-0.46[-0.84;-0.09],I2=82%) and fatigue(SMD:-0.34[-0.58;-0.10],I2=47%) remained significantly and after 4-to 6-months only anxiety(SMD:-0.14[-0.33;0.06],I2=0%). These significant effects were not observed in the meta-analyses of studies comparing PIP+BGA to BGA or PIP alone. Conclusion PIP with BGA was superior to non-behavioural interventions in improving biopsychosocial outcomes in CPaS. Process evaluation Further research is needed on ‘how’ and ‘when’ BGA should be provided in cancer rehabilitation.
Original languageEnglish
Publication statusPublished - 20 May 2022
EventPain Science in Motion IV - Maastricht, Netherlands
Duration: 19 May 202221 May 2022
https://painscienceinmotion.org/

Conference

ConferencePain Science in Motion IV
CountryNetherlands
CityMaastricht
Period19/05/2221/05/22
Internet address

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