The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.

Astrid Lahousse

The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.

Research output: Unpublished contribution to conference › Poster

Abstract

Introduction Behavioural graded activity (BGA) has gained acceptance in the field and appears foremost in psychological informed practices (PIP)[1]. However, no review has been published about the effect of BGA in cancer. Therefore, this systematic review with meta-analyses determined the effectiveness of PIP with BGA compared to (1)waitlists (WLC), (2)other interventions (OI), (3)PIP-, or (4)BGA alone in cancer patients and survivors (CPaS). Methods Three databases were screened for randomized controlled trials encompassing PIP with BGA in CPaS. Effect sizes of physical activity (PA), quality of life (QoL) and debilitating symptoms were inventoried. Subgroup analyses were undertaken to reduce heterogeneity(I2>50%). Results Thirty-three studies were included, comprising 4,330 participants. Significant effects of PIP+BGA comparing to WLC were found for anxiety(SMD:-1.29[-1.71;-0.86],I2=0%), fatigue(SMD:-0.86[-1.18;-0.54],I2=61%), depression(SMD:-0.79[-1.10;-0.48],I2=0%), functional impairment(SMD:-0.72[-0.95;-0.50],I2=0%), psychological distress(SMD:-0.58[-0.82;-0.34],I2=51%), PA(SMD:-0.58[-0.84;-0.32],I2=47% and SMD:-0.51[-0.90;-0.13],I2=0%), QoL(SMD:-0.38[-0.68;-0.09],I2=51%), social impairment(SMD:-0.33[-0.58;-0.08],I2=0%) and only the psychological distress(SMD:-0.89[-1.76;-0.02],I2=82%) remained significantly after 1-to 3-months. When comparing PIP+BGA to OI, significant effects were found for anxiety(SMD:-0.47[-0.88;-0.06],I2=83%), depression(SMD:-0.46[-0.84;-0.09],I2=82%), fatigue(SMD:-0.35[-0.51;-0.20],I2=48%), and PA(SMD:-0.26[-0.41;-0.11],I2=44%). After 1-to 3-months, anxiety(SMD:-1.54[-2.88;-0.21],I2=87%), depression(SMD:-0.46[-0.84;-0.09],I2=82%) and fatigue(SMD:-0.34[-0.58;-0.10],I2=47%) remained significantly and after 4-to 6-months only anxiety(SMD:-0.14[-0.33;0.06],I2=0%). These significant effects were not observed in the meta-analyses of studies comparing PIP+BGA to BGA or PIP alone. Conclusion PIP with BGA was superior to non-behavioural interventions in improving biopsychosocial outcomes in CPaS. Process evaluation Further research is needed on ‘how’ and ‘when’ BGA should be provided in cancer rehabilitation.

Original language	English
Publication status	Published - 20 May 2022
Event	Pain Science in Motion IV - Maastricht, Netherlands Duration: 19 May 2022 → 21 May 2022 https://painscienceinmotion.org/

Conference

Conference	Pain Science in Motion IV
Country	Netherlands
City	Maastricht
Period	19/05/22 → 21/05/22
Internet address	https://painscienceinmotion.org/

Cite this

@conference{6d534fad00d849cfbeafaf2c2885b141,

title = "The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.",

abstract = "Introduction Behavioural graded activity (BGA) has gained acceptance in the field and appears foremost in psychological informed practices (PIP)[1]. However, no review has been published about the effect of BGA in cancer. Therefore, this systematic review with meta-analyses determined the effectiveness of PIP with BGA compared to (1)waitlists (WLC), (2)other interventions (OI), (3)PIP-, or (4)BGA alone in cancer patients and survivors (CPaS). Methods Three databases were screened for randomized controlled trials encompassing PIP with BGA in CPaS. Effect sizes of physical activity (PA), quality of life (QoL) and debilitating symptoms were inventoried. Subgroup analyses were undertaken to reduce heterogeneity(I2>50{\%}). Results Thirty-three studies were included, comprising 4,330 participants. Significant effects of PIP+BGA comparing to WLC were found for anxiety(SMD:-1.29[-1.71;-0.86],I2=0{\%}), fatigue(SMD:-0.86[-1.18;-0.54],I2=61{\%}), depression(SMD:-0.79[-1.10;-0.48],I2=0{\%}), functional impairment(SMD:-0.72[-0.95;-0.50],I2=0{\%}), psychological distress(SMD:-0.58[-0.82;-0.34],I2=51{\%}), PA(SMD:-0.58[-0.84;-0.32],I2=47{\%} and SMD:-0.51[-0.90;-0.13],I2=0{\%}), QoL(SMD:-0.38[-0.68;-0.09],I2=51{\%}), social impairment(SMD:-0.33[-0.58;-0.08],I2=0{\%}) and only the psychological distress(SMD:-0.89[-1.76;-0.02],I2=82{\%}) remained significantly after 1-to 3-months. When comparing PIP+BGA to OI, significant effects were found for anxiety(SMD:-0.47[-0.88;-0.06],I2=83{\%}), depression(SMD:-0.46[-0.84;-0.09],I2=82{\%}), fatigue(SMD:-0.35[-0.51;-0.20],I2=48{\%}), and PA(SMD:-0.26[-0.41;-0.11],I2=44{\%}). After 1-to 3-months, anxiety(SMD:-1.54[-2.88;-0.21],I2=87{\%}), depression(SMD:-0.46[-0.84;-0.09],I2=82{\%}) and fatigue(SMD:-0.34[-0.58;-0.10],I2=47{\%}) remained significantly and after 4-to 6-months only anxiety(SMD:-0.14[-0.33;0.06],I2=0{\%}). These significant effects were not observed in the meta-analyses of studies comparing PIP+BGA to BGA or PIP alone. Conclusion PIP with BGA was superior to non-behavioural interventions in improving biopsychosocial outcomes in CPaS. Process evaluation Further research is needed on ‘how’ and ‘when’ BGA should be provided in cancer rehabilitation.",

author = "Astrid Lahousse",

year = "2022",

month = "5",

day = "20",

language = "English",

note = "null ; Conference date: 19-05-2022 Through 21-05-2022",

url = "https://painscienceinmotion.org/",

}

TY - CONF

T1 - The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.

AU - Lahousse, Astrid

PY - 2022/5/20

Y1 - 2022/5/20

N2 - Introduction Behavioural graded activity (BGA) has gained acceptance in the field and appears foremost in psychological informed practices (PIP)[1]. However, no review has been published about the effect of BGA in cancer. Therefore, this systematic review with meta-analyses determined the effectiveness of PIP with BGA compared to (1)waitlists (WLC), (2)other interventions (OI), (3)PIP-, or (4)BGA alone in cancer patients and survivors (CPaS). Methods Three databases were screened for randomized controlled trials encompassing PIP with BGA in CPaS. Effect sizes of physical activity (PA), quality of life (QoL) and debilitating symptoms were inventoried. Subgroup analyses were undertaken to reduce heterogeneity(I2>50%). Results Thirty-three studies were included, comprising 4,330 participants. Significant effects of PIP+BGA comparing to WLC were found for anxiety(SMD:-1.29[-1.71;-0.86],I2=0%), fatigue(SMD:-0.86[-1.18;-0.54],I2=61%), depression(SMD:-0.79[-1.10;-0.48],I2=0%), functional impairment(SMD:-0.72[-0.95;-0.50],I2=0%), psychological distress(SMD:-0.58[-0.82;-0.34],I2=51%), PA(SMD:-0.58[-0.84;-0.32],I2=47% and SMD:-0.51[-0.90;-0.13],I2=0%), QoL(SMD:-0.38[-0.68;-0.09],I2=51%), social impairment(SMD:-0.33[-0.58;-0.08],I2=0%) and only the psychological distress(SMD:-0.89[-1.76;-0.02],I2=82%) remained significantly after 1-to 3-months. When comparing PIP+BGA to OI, significant effects were found for anxiety(SMD:-0.47[-0.88;-0.06],I2=83%), depression(SMD:-0.46[-0.84;-0.09],I2=82%), fatigue(SMD:-0.35[-0.51;-0.20],I2=48%), and PA(SMD:-0.26[-0.41;-0.11],I2=44%). After 1-to 3-months, anxiety(SMD:-1.54[-2.88;-0.21],I2=87%), depression(SMD:-0.46[-0.84;-0.09],I2=82%) and fatigue(SMD:-0.34[-0.58;-0.10],I2=47%) remained significantly and after 4-to 6-months only anxiety(SMD:-0.14[-0.33;0.06],I2=0%). These significant effects were not observed in the meta-analyses of studies comparing PIP+BGA to BGA or PIP alone. Conclusion PIP with BGA was superior to non-behavioural interventions in improving biopsychosocial outcomes in CPaS. Process evaluation Further research is needed on ‘how’ and ‘when’ BGA should be provided in cancer rehabilitation.

AB - Introduction Behavioural graded activity (BGA) has gained acceptance in the field and appears foremost in psychological informed practices (PIP)[1]. However, no review has been published about the effect of BGA in cancer. Therefore, this systematic review with meta-analyses determined the effectiveness of PIP with BGA compared to (1)waitlists (WLC), (2)other interventions (OI), (3)PIP-, or (4)BGA alone in cancer patients and survivors (CPaS). Methods Three databases were screened for randomized controlled trials encompassing PIP with BGA in CPaS. Effect sizes of physical activity (PA), quality of life (QoL) and debilitating symptoms were inventoried. Subgroup analyses were undertaken to reduce heterogeneity(I2>50%). Results Thirty-three studies were included, comprising 4,330 participants. Significant effects of PIP+BGA comparing to WLC were found for anxiety(SMD:-1.29[-1.71;-0.86],I2=0%), fatigue(SMD:-0.86[-1.18;-0.54],I2=61%), depression(SMD:-0.79[-1.10;-0.48],I2=0%), functional impairment(SMD:-0.72[-0.95;-0.50],I2=0%), psychological distress(SMD:-0.58[-0.82;-0.34],I2=51%), PA(SMD:-0.58[-0.84;-0.32],I2=47% and SMD:-0.51[-0.90;-0.13],I2=0%), QoL(SMD:-0.38[-0.68;-0.09],I2=51%), social impairment(SMD:-0.33[-0.58;-0.08],I2=0%) and only the psychological distress(SMD:-0.89[-1.76;-0.02],I2=82%) remained significantly after 1-to 3-months. When comparing PIP+BGA to OI, significant effects were found for anxiety(SMD:-0.47[-0.88;-0.06],I2=83%), depression(SMD:-0.46[-0.84;-0.09],I2=82%), fatigue(SMD:-0.35[-0.51;-0.20],I2=48%), and PA(SMD:-0.26[-0.41;-0.11],I2=44%). After 1-to 3-months, anxiety(SMD:-1.54[-2.88;-0.21],I2=87%), depression(SMD:-0.46[-0.84;-0.09],I2=82%) and fatigue(SMD:-0.34[-0.58;-0.10],I2=47%) remained significantly and after 4-to 6-months only anxiety(SMD:-0.14[-0.33;0.06],I2=0%). These significant effects were not observed in the meta-analyses of studies comparing PIP+BGA to BGA or PIP alone. Conclusion PIP with BGA was superior to non-behavioural interventions in improving biopsychosocial outcomes in CPaS. Process evaluation Further research is needed on ‘how’ and ‘when’ BGA should be provided in cancer rehabilitation.

M3 - Poster

ER -

The Effect of Behavioural Graded Activity on Physical Activity Level, Health-Related Quality of Life and Symptom Management in Cancer Patients and Survivors: Systematic Review And Meta-Analysis.

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