The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

Ine Buffel; Alfred Meurs; Robrecht Raedt; Veerle de Herdt; Leen Decorte; Laurence Bertier; Jean Delbeke; Wytse Wadman; Kristl Vonck; Paul Boon

doi:10.1142/S0129065714300058

The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

Ine Buffel, Alfred Meurs, Robrecht Raedt, Veerle de Herdt, Leen Decorte, Laurence Bertier, Jean Delbeke, Wytse Wadman, Kristl Vonck, Paul Boon

Neuroprotection & Neuromodulation

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.

Original language	English
Article number	1430005
Number of pages	10
Journal	International Journal of Neural Systems
Volume	24
Issue number	2
DOIs	https://doi.org/10.1142/S0129065714300058
Publication status	Published - Mar 2014

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Buffel, I., Meurs, A., Raedt, R., de Herdt, V., Decorte, L., Bertier, L., Delbeke, J., Wadman, W., Vonck, K., & Boon, P. (2014). The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats. International Journal of Neural Systems, 24(2), [1430005]. https://doi.org/10.1142/S0129065714300058

Buffel, Ine ; Meurs, Alfred ; Raedt, Robrecht ; de Herdt, Veerle ; Decorte, Leen ; Bertier, Laurence ; Delbeke, Jean ; Wadman, Wytse ; Vonck, Kristl ; Boon, Paul. / The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats. In: International Journal of Neural Systems. 2014 ; Vol. 24, No. 2.

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title = "The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats",

abstract = "Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.",

keywords = "Animals, Deep Brain Stimulation, Electric Stimulation Therapy, Electrodes, Implanted, Evoked Potentials, Motor, Male, Motor Cortex, Poisson Distribution, Rats, Rats, Wistar, Time Factors",

author = "Ine Buffel and Alfred Meurs and Robrecht Raedt and {de Herdt}, Veerle and Leen Decorte and Laurence Bertier and Jean Delbeke and Wytse Wadman and Kristl Vonck and Paul Boon",

year = "2014",

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doi = "10.1142/S0129065714300058",

language = "English",

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Buffel, I, Meurs, A, Raedt, R, de Herdt, V, Decorte, L, Bertier, L, Delbeke, J, Wadman, W, Vonck, K & Boon, P 2014, 'The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats', International Journal of Neural Systems, vol. 24, no. 2, 1430005. https://doi.org/10.1142/S0129065714300058

The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats. / Buffel, Ine; Meurs, Alfred; Raedt, Robrecht; de Herdt, Veerle; Decorte, Leen; Bertier, Laurence; Delbeke, Jean; Wadman, Wytse; Vonck, Kristl; Boon, Paul.

In: International Journal of Neural Systems, Vol. 24, No. 2, 1430005, 03.2014.

Research output: Contribution to journal › Article › peer-review

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T1 - The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

AU - Buffel, Ine

AU - Meurs, Alfred

AU - Raedt, Robrecht

AU - de Herdt, Veerle

AU - Decorte, Leen

AU - Bertier, Laurence

AU - Delbeke, Jean

AU - Wadman, Wytse

AU - Vonck, Kristl

AU - Boon, Paul

PY - 2014/3

Y1 - 2014/3

N2 - Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.

AB - Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.

KW - Animals

KW - Deep Brain Stimulation

KW - Electric Stimulation Therapy

KW - Electrodes, Implanted

KW - Evoked Potentials, Motor

KW - Male

KW - Motor Cortex

KW - Poisson Distribution

KW - Rats

KW - Rats, Wistar

KW - Time Factors

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DO - 10.1142/S0129065714300058

M3 - Article

C2 - 24475897

VL - 24

JO - International Journal of Neural Systems

JF - International Journal of Neural Systems

SN - 0129-0657

IS - 2

M1 - 1430005

ER -

The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

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