The European epidemiological study (EURALOC) on radiation-induced lens opacities among interventional cardiologists

Lara Struelens, Peter Covens, M Benadjaoud, A Auvinen, E Gianicolo, A Wegener, Joanna Karolina Domienik-Andrzejewska, Eleftheria Carinou, Octavian Dragusin, Pedro Teles, Olivera Ciraj-Bjelac, Anders Widmark, MG Andreassi, Renato Padovani

Research output: Contribution to journalMeeting abstract (Journal)



Low dose radiation effect on the eye lens has been an area of interest in numerous epidemiological studies. The European epidemiological study EURALOC was conducted between December 2014 and May 2017 with the objective to investigate a possible dose-response relationship by targeting a sufficiently large study population with reasonably high exposure levels, namely interventional cardiologists (ICs).

In total 393 subjects have been recruited in the exposed group, they have completed study questionnaires on work history and risk factors for lens opacities and received an ophthalmological examination. As for the control group, 243 subjects have been recruited, completing the same questionnaire on risk factors for lens opacities and ophthalmological examination. Efforts have been made to develop 2 approaches to assess retrospectively the cumulative eye lens doses of the recruited cardiologists. The first approach is based on the individual work history in combination with published eye lens dose data, while the second approach is based on individual routine whole body dosimetry and its conversion to eye lens dose. Innovative approaches have been used for the statistical analysis by using a mixed linear regression and polytomous logistic regression approach, which permit a correct modelling of the lens opacities by taking into account the correlation of the soring outcomes of both eyes in the radio-induced risk estimation as well as dose estimation uncertainties.

More than 200 dose measurements have been performed in clinical practice to validate both calculation approaches. 1st approach resulted in the most satisfactory with an average ratio between measured and calculated eye lens dose of 0.96 [95%CI: 0.87-1.09] for the left eye and 0.50 [95%CI: 0.44-0.56] for the right eye. The analyses established a significant impact of radiation dose in the occurrence of PSC opacities with a relative risk for ICs of OR = 2.62 (95%CI 1.35–5.08).

A linear no threshold model provided the better fit of the lens opacities dose-response relationship with an excess relative risk per Gy equal to 1.31 (95% CI 0.13–3.32)
Original languageEnglish
Pages (from-to)106-106
Number of pages1
JournalPhysica Medica
Issue numberS2
Publication statusPublished - Dec 2018
Event10th National Congress of the Associazione Italiana di Fisica Medica - Bari, Italy
Duration: 12 Apr 201815 Apr 2018


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