The events that may contribute to subgingival dysbiosis: a focus on the interplay between iron, sulfide and oxygen

Kanchana Chathoth, Bénédicte Martin, Pierre Cornelis, Stéven Yvenou, Martine Bonnaure-Mallet, Christine Baysse

Research output: Contribution to journalArticle

Abstract

This minireview considers the disruption of the host-microbiota harmless symbiosis in the subgingival niche. The establishment of a chronic infection by subversion of a commensal microbiota results from a complex and multiparametric sequence of events. This review narrows down to the interplay between oxygen, iron and sulfide that can result in a vicious cycle that would favour peroxigenic and glutathione producing streptococci as well as sulfidogenic anaerobic pathogens in the subgingival niche. We propose hypothesis and discuss strategies for the therapeutic modulation of the microbiota to prevent periodontitis and promote oral health.

Original languageEnglish
JournalFEMS Microbiology Letters
DOIs
Publication statusE-pub ahead of print - 20 Jun 2020

Bibliographical note

© FEMS 2020.

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