The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study

A J C Slooter; M Cruts; A Hofman; P J Koudstaal; D van der Kuip; M A J de Ridder; J C M Witteman; M M B Breteler; C Van Broeckhoven; C M van Duijn

doi:10.1212/01.wnl.0000118302.66674.e1

The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study

A J C Slooter, M Cruts, A Hofman, P J Koudstaal, D van der Kuip, M A J de Ridder, J C M Witteman, M M B Breteler, C Van Broeckhoven, C M van Duijn

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

Original language	English
Pages (from-to)	1196-1198
Number of pages	3
Journal	Neurology
Volume	62
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000118302.66674.e1
Publication status	Published - 13 Apr 2004

Keywords

Age Distribution
Aged
Apolipoproteins E/genetics
Cohort Studies
Dementia/epidemiology
Female
Genotype
Humans
Incidence
Male
Middle Aged
Myocardial Infarction/epidemiology
Netherlands/epidemiology
Proportional Hazards Models
Risk
Risk Assessment
Sex Distribution
Stroke/epidemiology
Whites/genetics

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10.1212/01.wnl.0000118302.66674.e1

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title = "The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study",

abstract = "It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.",

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author = "Slooter, {A J C} and M Cruts and A Hofman and Koudstaal, {P J} and {van der Kuip}, D and {de Ridder}, {M A J} and Witteman, {J C M} and Breteler, {M M B} and {Van Broeckhoven}, C and {van Duijn}, {C M}",

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The impact of APOE on myocardial infarction, stroke, and dementia : the Rotterdam Study. / Slooter, A J C; Cruts, M; Hofman, A; Koudstaal, P J; van der Kuip, D; de Ridder, M A J; Witteman, J C M; Breteler, M M B; Van Broeckhoven, C; van Duijn, C M.

In: Neurology, Vol. 62, No. 7, 13.04.2004, p. 1196-1198.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The impact of APOE on myocardial infarction, stroke, and dementia

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AU - Slooter, A J C

AU - Cruts, M

AU - Hofman, A

AU - Koudstaal, P J

AU - van der Kuip, D

AU - de Ridder, M A J

AU - Witteman, J C M

AU - Breteler, M M B

AU - Van Broeckhoven, C

AU - van Duijn, C M

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AB - It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

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KW - Cohort Studies

KW - Dementia/epidemiology

KW - Female

KW - Genotype

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KW - Incidence

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/epidemiology

KW - Netherlands/epidemiology

KW - Proportional Hazards Models

KW - Risk

KW - Risk Assessment

KW - Sex Distribution

KW - Stroke/epidemiology

KW - Whites/genetics

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JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -

The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study

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Keywords

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