The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression

Chris Baeken; Rudi De Raedt; Axel Bossuyt; C. Van Hove; John Mertens; André Dobbeleir; P. Blanckaert; I. Goethals

The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression

Chris Baeken, Rudi De Raedt, Axel Bossuyt, C. Van Hove, John Mertens, André Dobbeleir, P. Blanckaert, I. Goethals

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system.

METHODS: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT(2A) receptor binding indices (BI) measured with ¹²³I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients.

RESULTS: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT(2A) receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT(2A) receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT(2A) receptor uptake values.

CONCLUSIONS: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT(2A) receptor BI in the DLPFC and in the hippocampus in different ways.

Original language	English
Pages (from-to)	104-111
Number of pages	8
Journal	Brain Stimul
Volume	4
Issue number	2
Publication status	Published - 2011

Keywords

HF-rTMS
treatment
Unipolar depression
Serotonin 2A receptor
Serotonin
depression

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http://www.ncbi.nlm.nih.gov/pubmed?term=The%20impactt%20of%20HF-rTMS%20treatment%20on%20Serotonin%202A%20receptors%20in%20unipolar%20depression

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Baeken, C., De Raedt, R., Bossuyt, A., Van Hove, C., Mertens, J., Dobbeleir, A., Blanckaert, P., & Goethals, I. (2011). The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression. Brain Stimul, 4(2), 104-111. http://www.ncbi.nlm.nih.gov/pubmed?term=The%20impactt%20of%20HF-rTMS%20treatment%20on%20Serotonin%202A%20receptors%20in%20unipolar%20depression

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title = "The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression",

abstract = "BACKGROUND: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system. METHODS: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT(2A) receptor binding indices (BI) measured with ¹²³I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients. RESULTS: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT(2A) receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT(2A) receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT(2A) receptor uptake values. CONCLUSIONS: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT(2A) receptor BI in the DLPFC and in the hippocampus in different ways.",

keywords = "HF-rTMS, treatment, Unipolar depression, Serotonin 2A receptor, Serotonin, depression",

author = "Chris Baeken and {De Raedt}, Rudi and Axel Bossuyt and {Van Hove}, C. and John Mertens and Andr{\'e} Dobbeleir and P. Blanckaert and I. Goethals",

year = "2011",

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Baeken, C, De Raedt, R, Bossuyt, A, Van Hove, C, Mertens, J, Dobbeleir, A, Blanckaert, P & Goethals, I 2011, 'The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression', Brain Stimul, vol. 4, no. 2, pp. 104-111. <http://www.ncbi.nlm.nih.gov/pubmed?term=The%20impactt%20of%20HF-rTMS%20treatment%20on%20Serotonin%202A%20receptors%20in%20unipolar%20depression>

TY - JOUR

T1 - The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression

AU - Baeken, Chris

AU - De Raedt, Rudi

AU - Bossuyt, Axel

AU - Van Hove, C.

AU - Mertens, John

AU - Dobbeleir, André

AU - Blanckaert, P.

AU - Goethals, I.

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system. METHODS: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT(2A) receptor binding indices (BI) measured with ¹²³I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients. RESULTS: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT(2A) receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT(2A) receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT(2A) receptor uptake values. CONCLUSIONS: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT(2A) receptor BI in the DLPFC and in the hippocampus in different ways.

AB - BACKGROUND: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system. METHODS: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT(2A) receptor binding indices (BI) measured with ¹²³I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients. RESULTS: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT(2A) receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT(2A) receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT(2A) receptor uptake values. CONCLUSIONS: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT(2A) receptor BI in the DLPFC and in the hippocampus in different ways.

KW - HF-rTMS

KW - treatment

KW - Unipolar depression

KW - Serotonin 2A receptor

KW - Serotonin

KW - depression

M3 - Article

SN - 1935-861X

VL - 4

SP - 104

EP - 111

JO - Brain Stimul

JF - Brain Stimul

IS - 2

ER -

The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression

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Keywords

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