The impact of one session of HF-rTMS on salivary cortisol in healthy female subjects.

Chris Baeken, Rudi De Raedt, L. Leyman, J. Schiettecatte, Kris Poppe, Leonard Kaufman, Margot HAES, M.a. Vanderhasselt, Ellen Anckaert, Hugo D'Haenen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Previous studies in healthy volunteers reported a possible impact of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on stress hormones, like cortisol. In this sham-controlled, "single blind", crossover study, we examined whether HF-rTMS had an effect on the hypothalamic-pituitary-adrenal (HPA) axis, by analysing salivary cortisol levels. Two studies were conducted. First, HF-rTMS on the left dorsolateral prefrontal cortex (DLPFC) was performed in 28 young healthy female volunteers. Second, in a comparable, but different group of 26 healthy females, HF-rTMS was performed on the right DLPFC. Salivary cortisol levels were assessed before, immediately after and 30 min after real and sham HF-rTMS. We found no support for the hypothesis that one single session of HF-rTMS on the left or the right DLPFC has an immediate or delayed impact on the HPA-axis, as measured by salivary cortisol. Although we controlled for several methodological problems in HF-rTMS research, the hypothesis that one single session of HF-rTMS on the left or on the right DLPFC can influence the HPA-axis in healthy volunteers was not supported.
Original languageEnglish
Pages (from-to)586-590
Number of pages5
JournalWorld J Biol Psychiatry
Volume10
Issue number4 Pt 2
Publication statusPublished - 2009

Keywords

  • Adult
  • Arousal/physiology
  • Cross-Over Studies
  • Dominance, Cerebral/physiology
  • Female
  • Humans
  • Hydrocortisone/blood
  • Hypothalamo-Hypophyseal System/physiology
  • Pituitary-Adrenal System/physiology
  • Prefrontal Cortex/physiology
  • Reproducibility of Results
  • Saliva/chemistry
  • Single-Blind Method
  • Transcranial Magnetic Stimulation
  • Young Adult

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