The impact of optimized mRNA on cancer vaccination

Research output: Unpublished contribution to conferenceUnpublished abstract

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Abstract

Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.
Original languageEnglish
Pages1
Number of pages1
Publication statusPublished - 7 Feb 2020
EventBACR Annual Meeting 2020: Cancer metastasis: From bedside to bench - Vrije Universiteit Brussel, Campus Jette, Brussels, Belgium
Duration: 7 Feb 20207 Feb 2020
Conference number: 26th
https://www.bacr.be/program/

Conference

ConferenceBACR Annual Meeting 2020
CountryBelgium
CityBrussels
Period7/02/207/02/20
Internet address

Keywords

  • mRNA
  • Cancer
  • Immunotherapy

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