The impact of optimized mRNA on cancer vaccination

Wout De Mey; Quentin Lecocq; Dorien Autaers; Karine Breckpot; Kris Thielemans; Lorenzo Franceschini

The impact of optimized mRNA on cancer vaccination

Wout De Mey, Quentin Lecocq, Dorien Autaers, Karine Breckpot, Kris Thielemans, Lorenzo Franceschini

Research output: Unpublished contribution to conference › Unpublished abstract

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Abstract

Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

Original language	English
Pages	1
Number of pages	1
Publication status	Published - 7 Feb 2020
Event	BACR Annual Meeting 2020: Cancer metastasis: From bedside to bench - Vrije Universiteit Brussel, Campus Jette, Brussels, Belgium Duration: 7 Feb 2020 → 7 Feb 2020 Conference number: 26th https://www.bacr.be/program/

Conference

Conference	BACR Annual Meeting 2020
Country	Belgium
City	Brussels
Period	7/02/20 → 7/02/20
Internet address	https://www.bacr.be/program/

Keywords

mRNA
Cancer
Immunotherapy

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BACR_ABSTRACT_Wout de Mey_FinalFinal published version, 16.9 KBLicence: Unspecified

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SRP48: Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)
Vanderkerken, K., Thielemans, K., Vanderkerken, K. & Breckpot, K.
1/11/17 → 31/10/24
Project: Fundamental
VOPPU95: VOPPU95 - Prijs kankeronderzoek - Wout De Mey
Breckpot, K., Thielemans, K. & De Mey, W.
1/01/21 → 30/06/21
Project: Fundamental

Cite this

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title = "The impact of optimized mRNA on cancer vaccination",

abstract = "Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.",

keywords = "mRNA, Cancer, Immunotherapy",

author = "{De Mey}, Wout and Quentin Lecocq and Dorien Autaers and Karine Breckpot and Kris Thielemans and Lorenzo Franceschini",

year = "2020",

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language = "English",

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T1 - The impact of optimized mRNA on cancer vaccination

AU - De Mey, Wout

AU - Lecocq, Quentin

AU - Autaers, Dorien

AU - Breckpot, Karine

AU - Thielemans, Kris

AU - Franceschini, Lorenzo

N1 - Conference code: 26th

PY - 2020/2/7

Y1 - 2020/2/7

N2 - Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

AB - Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

KW - mRNA

KW - Cancer

KW - Immunotherapy

M3 - Unpublished abstract

SP - 1

T2 - BACR Annual Meeting 2020

Y2 - 7 February 2020 through 7 February 2020

ER -

The impact of optimized mRNA on cancer vaccination

Abstract

Conference

Keywords

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Projects

SRP48: Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)

VOPPU95: VOPPU95 - Prijs kankeronderzoek - Wout De Mey

Cite this