The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021

Marco Moretti; Véronique Y Miendje Deyi; Deborah De Geyter; Ingrid Wybo; Marc Claus; Joop Jonckheer; Philippe Clevenbergh; Nicolas Dauby

doi:10.1016/j.ajic.2023.08.020

The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021

Marco Moretti, Véronique Y Miendje Deyi, Deborah De Geyter, Ingrid Wybo, Marc Claus, Joop Jonckheer, Philippe Clevenbergh, Nicolas Dauby

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The effect of the Coronavirus Disease 2019 (COVID-19) pandemic on gram-negative bacteria nonsusceptibility to antibiotics is unclear. Methods: Between January 1, 2010, and December 31, 2021, the respiratory samples of intensive care unit patients at 3 University Hospitals in Brussels were retrieved. Based on the nonsusceptibility to antimicrobial classes, drug-resistance patterns were defined as multi-drug-resistant, extensively drug-resistant, and pan-drug-resistant. The study time frame was divided into 6 periods of 2 years each, and the impact of the COVID-19 pandemic (last period: 2020-2021) was assessed. Results: During the current study, 10,577 samples were identified from 5,889 patients. While a significant augmentation of multi-drug-resistant isolates was noticed once comparing 2 prepandemic periods (2012-2013 and 2014-2015), all 3 patterns of nonsusceptibility significantly increased, comparing the years before and throughout the COVID-19 pandemic (2018-2019 and 2020-2021). Globally, the greatest increase in antimicrobial nonsusceptibility, comparing the last 2 periods, was reported for piperacillin-tazobactam (from 28% to 38%). Pseudomonas aeruginosa was the most isolated species, and the most involved in the appearance of resistance, with an augmentation of nonsusceptibility percentage to meropenem of 22% (from 25% to 47%), between the prepandemic and the pandemic periods. Conclusions: The COVID-19 pandemic was associated with increasing trends of antimicrobial resistance in respiratory samples of patients admitted to the intensive care units in university hospitals with well-implemented antibiotic stewardship programs.

Original language	English
Pages (from-to)	305-311
Number of pages <span style="color:red"p> <font size="1.5"> ✽ </span> </font>	7
Journal	American journal of infection control
Volume	52
Issue number	3
Early online date	29 Aug 2023
DOIs	https://doi.org/10.1016/j.ajic.2023.08.020
Publication status	Published - Mar 2024

Bibliographical note

Funding Information:
We would like to express gratitude for the logistic support offered by the infectious diseases coordinating study team of UZ Brussel, CHU Saint Pierre and CHU Brugmann. Particularly, we would like to thank BYG4lab which provided the INFECTIO.GLOBAL software through which data collection was performed in CHU Saint Pierre and CHU Brugmann, Mr. Witdouck Arne (Data Manager—UZ Brussel) for its help on data cleaning, and Mr. Delforge Marc (Statistician—CHU Saint Pierre) for its check on statistical analyses.

Publisher Copyright:
© 2023 Association for Professionals in Infection Control and Epidemiology, Inc.

Keywords

Gram-negative bacteria
antibiotic susceptibility
respiratory samples
intensive care unit
Ventilator-associated pneumonia
Coronavirus Disease 2019

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10.1016/j.ajic.2023.08.020

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Moretti, M., Miendje Deyi, V. Y., De Geyter, D., Wybo, I., Claus, M., Jonckheer, J., Clevenbergh, P., & Dauby, N. (2024). The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021. American journal of infection control, 52(3), 305-311. https://doi.org/10.1016/j.ajic.2023.08.020

Moretti, Marco ; Miendje Deyi, Véronique Y ; De Geyter, Deborah ; Wybo, Ingrid ; Claus, Marc ; Jonckheer, Joop ; Clevenbergh, Philippe ; Dauby, Nicolas. / The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021. In: American journal of infection control. 2024 ; Vol. 52, No. 3. pp. 305-311.

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title = "The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021",

abstract = "Background: The effect of the Coronavirus Disease 2019 (COVID-19) pandemic on gram-negative bacteria nonsusceptibility to antibiotics is unclear. Methods: Between January 1, 2010, and December 31, 2021, the respiratory samples of intensive care unit patients at 3 University Hospitals in Brussels were retrieved. Based on the nonsusceptibility to antimicrobial classes, drug-resistance patterns were defined as multi-drug-resistant, extensively drug-resistant, and pan-drug-resistant. The study time frame was divided into 6 periods of 2 years each, and the impact of the COVID-19 pandemic (last period: 2020-2021) was assessed. Results: During the current study, 10,577 samples were identified from 5,889 patients. While a significant augmentation of multi-drug-resistant isolates was noticed once comparing 2 prepandemic periods (2012-2013 and 2014-2015), all 3 patterns of nonsusceptibility significantly increased, comparing the years before and throughout the COVID-19 pandemic (2018-2019 and 2020-2021). Globally, the greatest increase in antimicrobial nonsusceptibility, comparing the last 2 periods, was reported for piperacillin-tazobactam (from 28% to 38%). Pseudomonas aeruginosa was the most isolated species, and the most involved in the appearance of resistance, with an augmentation of nonsusceptibility percentage to meropenem of 22% (from 25% to 47%), between the prepandemic and the pandemic periods. Conclusions: The COVID-19 pandemic was associated with increasing trends of antimicrobial resistance in respiratory samples of patients admitted to the intensive care units in university hospitals with well-implemented antibiotic stewardship programs.",

keywords = "Gram-negative bacteria, antibiotic susceptibility, respiratory samples, intensive care unit, Ventilator-associated pneumonia, Coronavirus Disease 2019",

author = "Marco Moretti and {Miendje Deyi}, {V{\'e}ronique Y} and {De Geyter}, Deborah and Ingrid Wybo and Marc Claus and Joop Jonckheer and Philippe Clevenbergh and Nicolas Dauby",

note = "Funding Information: We would like to express gratitude for the logistic support offered by the infectious diseases coordinating study team of UZ Brussel, CHU Saint Pierre and CHU Brugmann. Particularly, we would like to thank BYG4lab which provided the INFECTIO.GLOBAL software through which data collection was performed in CHU Saint Pierre and CHU Brugmann, Mr. Witdouck Arne (Data Manager—UZ Brussel) for its help on data cleaning, and Mr. Delforge Marc (Statistician—CHU Saint Pierre) for its check on statistical analyses. Publisher Copyright: {\textcopyright} 2023 Association for Professionals in Infection Control and Epidemiology, Inc.",

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Moretti, M, Miendje Deyi, VY, De Geyter, D , Wybo, I, Claus, M, Jonckheer, J, Clevenbergh, P & Dauby, N 2024, 'The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021', American journal of infection control, vol. 52, no. 3, pp. 305-311. https://doi.org/10.1016/j.ajic.2023.08.020

The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021. / Moretti, Marco; Miendje Deyi, Véronique Y; De Geyter, Deborah ; Wybo, Ingrid; Claus, Marc; Jonckheer, Joop; Clevenbergh, Philippe; Dauby, Nicolas.

In: American journal of infection control, Vol. 52, No. 3, 03.2024, p. 305-311.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021

AU - Moretti, Marco

AU - Miendje Deyi, Véronique Y

AU - De Geyter, Deborah

AU - Wybo, Ingrid

AU - Claus, Marc

AU - Jonckheer, Joop

AU - Clevenbergh, Philippe

AU - Dauby, Nicolas

N1 - Funding Information: We would like to express gratitude for the logistic support offered by the infectious diseases coordinating study team of UZ Brussel, CHU Saint Pierre and CHU Brugmann. Particularly, we would like to thank BYG4lab which provided the INFECTIO.GLOBAL software through which data collection was performed in CHU Saint Pierre and CHU Brugmann, Mr. Witdouck Arne (Data Manager—UZ Brussel) for its help on data cleaning, and Mr. Delforge Marc (Statistician—CHU Saint Pierre) for its check on statistical analyses. Publisher Copyright: © 2023 Association for Professionals in Infection Control and Epidemiology, Inc.

PY - 2024/3

Y1 - 2024/3

N2 - Background: The effect of the Coronavirus Disease 2019 (COVID-19) pandemic on gram-negative bacteria nonsusceptibility to antibiotics is unclear. Methods: Between January 1, 2010, and December 31, 2021, the respiratory samples of intensive care unit patients at 3 University Hospitals in Brussels were retrieved. Based on the nonsusceptibility to antimicrobial classes, drug-resistance patterns were defined as multi-drug-resistant, extensively drug-resistant, and pan-drug-resistant. The study time frame was divided into 6 periods of 2 years each, and the impact of the COVID-19 pandemic (last period: 2020-2021) was assessed. Results: During the current study, 10,577 samples were identified from 5,889 patients. While a significant augmentation of multi-drug-resistant isolates was noticed once comparing 2 prepandemic periods (2012-2013 and 2014-2015), all 3 patterns of nonsusceptibility significantly increased, comparing the years before and throughout the COVID-19 pandemic (2018-2019 and 2020-2021). Globally, the greatest increase in antimicrobial nonsusceptibility, comparing the last 2 periods, was reported for piperacillin-tazobactam (from 28% to 38%). Pseudomonas aeruginosa was the most isolated species, and the most involved in the appearance of resistance, with an augmentation of nonsusceptibility percentage to meropenem of 22% (from 25% to 47%), between the prepandemic and the pandemic periods. Conclusions: The COVID-19 pandemic was associated with increasing trends of antimicrobial resistance in respiratory samples of patients admitted to the intensive care units in university hospitals with well-implemented antibiotic stewardship programs.

AB - Background: The effect of the Coronavirus Disease 2019 (COVID-19) pandemic on gram-negative bacteria nonsusceptibility to antibiotics is unclear. Methods: Between January 1, 2010, and December 31, 2021, the respiratory samples of intensive care unit patients at 3 University Hospitals in Brussels were retrieved. Based on the nonsusceptibility to antimicrobial classes, drug-resistance patterns were defined as multi-drug-resistant, extensively drug-resistant, and pan-drug-resistant. The study time frame was divided into 6 periods of 2 years each, and the impact of the COVID-19 pandemic (last period: 2020-2021) was assessed. Results: During the current study, 10,577 samples were identified from 5,889 patients. While a significant augmentation of multi-drug-resistant isolates was noticed once comparing 2 prepandemic periods (2012-2013 and 2014-2015), all 3 patterns of nonsusceptibility significantly increased, comparing the years before and throughout the COVID-19 pandemic (2018-2019 and 2020-2021). Globally, the greatest increase in antimicrobial nonsusceptibility, comparing the last 2 periods, was reported for piperacillin-tazobactam (from 28% to 38%). Pseudomonas aeruginosa was the most isolated species, and the most involved in the appearance of resistance, with an augmentation of nonsusceptibility percentage to meropenem of 22% (from 25% to 47%), between the prepandemic and the pandemic periods. Conclusions: The COVID-19 pandemic was associated with increasing trends of antimicrobial resistance in respiratory samples of patients admitted to the intensive care units in university hospitals with well-implemented antibiotic stewardship programs.

KW - Gram-negative bacteria

KW - antibiotic susceptibility

KW - respiratory samples

KW - intensive care unit

KW - Ventilator-associated pneumonia

KW - Coronavirus Disease 2019

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DO - 10.1016/j.ajic.2023.08.020

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C2 - 37652308

VL - 52

SP - 305

EP - 311

JO - American journal of infection control

JF - American journal of infection control

SN - 0196-6553

IS - 3

ER -

The impact of the COVID-19 pandemic on Gram-negative bacteria susceptibility patterns in respiratory samples of intensive care units in the Brussels Capital Region, 2010-2021

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