Abstract
The influence of shear flow on the polymorphism of the medical compound ROY was investigated using constant shear microfluidic device. This device was developed to study the effect of shear on protein crystallization but it can be used for a wide range of applications [1]. A constant shear rate is generated by a lid-driven flow configuration inside a rotating circular microfluidic channel. Confinement in a microfluidic channel combined with shear rates up to 100 s-1 suppress the nucleation of metastable polymorphs of R0Y.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 679-680 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419017 |
| Publication status | Published - Oct 2020 |
| Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online Duration: 4 Oct 2020 → 9 Oct 2020 |
Publication series
| Name | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 |
|---|---|
| City | Virtual, Online |
| Period | 4/10/20 → 9/10/20 |
Bibliographical note
Funding Information:DM and SS are supported by BELSPO (ESA-Prodex AO-2004-070). WDM, MC and PG acknowledge support from The European Research Council (grant number 679033EVODIS ERC-2015-STG).
Publisher Copyright:
© 2020 CBMS-0001
Keywords
- Microfluidics
- Nucleation
- Polymorphism
- Raman Spectroscopy
- Shear
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