The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians

Gerontopole Brussels Study group; Veerle Knoop; Axelle Costenoble; Aziz Debain; Roberta Vella Azzopardi; Sofie Vermeiren; Sven van Laere; Bart Jansen; Aldo Scafoglieri; Ivan Bautmans; Dominique Verté; Ingo Beyer; Mirko Petrovic; Liesbeth De Donder; Tinie Kardol; Gina Rossi; Peter Clarys; Erik Cattrysse; Paul de Hert

doi:10.1016/j.exger.2021.111440

The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians

Gerontopole Brussels Study group, Veerle Knoop, Axelle Costenoble, Aziz Debain, Roberta Vella Azzopardi, Sofie Vermeiren, Sven van Laere, Bart Jansen, Aldo Scafoglieri, Ivan Bautmans, Dominique Verté, Ingo Beyer, Mirko Petrovic, Liesbeth De Donder, Tinie Kardol, Gina Rossi, Peter Clarys, Erik Cattrysse, Paul de Hert

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Abstract

Introduction: Low grip work and high feelings of self-perceived fatigue could be an early characteristic of decline in reserve capacity, which comes to full expression as physical frailty in a later stage. When grip work and self-perceived fatigue can be identified as characteristics differentiating between robustness and pre-frailty it might allow to identify pre-frailty earlier. Therefore, this study aimed to investigate whether the combination of grip work and self-perceived fatigue is related to pre-frailty in well-functioning older adults aged 80 and over. Methods: Four-hundred and five community-dwelling older adults aged 80 and over (214 robust and 191 pre-frail) were assessed for muscle endurance (grip Work corrected for body weight (GW_bw)), self-perceived fatigue (MFI-20) and frailty state (Fried Frailty Index, FFI). A Capacity to Perceived Vitality ratio (CPV) was calculated by dividing GW_bw by the MFI-20 scores. ANCOVA analysis (corrected for age and gender) was used to compare robust and pre-frail older adults, and binary logistic regressions were applied to analyze the relationship between CPV and pre-frailty status. Results: Pre-frail older adults who scored negative on the exhaustion item of the FFI still showed significantly lower GW (p < 0.001), CPV ratios (p < 0.001) and higher self-perceived fatigue (p < 0.05) compared to the robust ones. The likelihood for pre-frailty related significantly to higher age, being men and lower CPV ratios. In women, every unit increase in CPV ratio decreased the likelihood for pre-frailty by 78% (OR 0.22; 95% CI: 0.11–0.44), for men this effect was less strong (34%, OR 0.66; 95% CI: 0.47–0.93). Conclusions: Pre-frail community-dwelling persons aged 80 years and over without clinical signs of exhaustion on the FFI still experience significantly higher fatigue levels (lower Grip Work, higher self-perceived fatigue and lower CPV levels) compared to robust ones. CPV ratio could therefore be a good tool to identify subclinical fatigue in the context of physical (pre-)frailty.

Original language	English
Article number	111440
Journal	Experimental Gerontology
Volume	152
DOIs	https://doi.org/10.1016/j.exger.2021.111440
Publication status	Published - Sept 2021

Bibliographical note

Keywords

Aged
Community-dwelling
Fatigue
Handgrip
Muscle endurance
Pre-frailty
Vitality

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10.1016/j.exger.2021.111440

Knoop_Experimental Gerontology_2021_152_111440Accepted author manuscript, 620 KBLicence: CC BY-NC-ND

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Gerontopole Brussels Study group, Knoop, V., Costenoble, A., Debain, A., Vella Azzopardi, R., Vermeiren, S., van Laere, S., Jansen, B., Scafoglieri, A., Bautmans, I., Verté, D., Beyer, I., Petrovic, M., De Donder, L., Kardol, T., Rossi, G., Clarys, P., Cattrysse, E., & de Hert, P. (2021). The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians. Experimental Gerontology, 152, Article 111440. https://doi.org/10.1016/j.exger.2021.111440

@article{8834d42738024698ba37a9a084e8f2ee,

title = "The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians",

abstract = "Introduction: Low grip work and high feelings of self-perceived fatigue could be an early characteristic of decline in reserve capacity, which comes to full expression as physical frailty in a later stage. When grip work and self-perceived fatigue can be identified as characteristics differentiating between robustness and pre-frailty it might allow to identify pre-frailty earlier. Therefore, this study aimed to investigate whether the combination of grip work and self-perceived fatigue is related to pre-frailty in well-functioning older adults aged 80 and over. Methods: Four-hundred and five community-dwelling older adults aged 80 and over (214 robust and 191 pre-frail) were assessed for muscle endurance (grip Work corrected for body weight (GW_bw)), self-perceived fatigue (MFI-20) and frailty state (Fried Frailty Index, FFI). A Capacity to Perceived Vitality ratio (CPV) was calculated by dividing GW_bw by the MFI-20 scores. ANCOVA analysis (corrected for age and gender) was used to compare robust and pre-frail older adults, and binary logistic regressions were applied to analyze the relationship between CPV and pre-frailty status. Results: Pre-frail older adults who scored negative on the exhaustion item of the FFI still showed significantly lower GW (p < 0.001), CPV ratios (p < 0.001) and higher self-perceived fatigue (p < 0.05) compared to the robust ones. The likelihood for pre-frailty related significantly to higher age, being men and lower CPV ratios. In women, every unit increase in CPV ratio decreased the likelihood for pre-frailty by 78% (OR 0.22; 95% CI: 0.11–0.44), for men this effect was less strong (34%, OR 0.66; 95% CI: 0.47–0.93). Conclusions: Pre-frail community-dwelling persons aged 80 years and over without clinical signs of exhaustion on the FFI still experience significantly higher fatigue levels (lower Grip Work, higher self-perceived fatigue and lower CPV levels) compared to robust ones. CPV ratio could therefore be a good tool to identify subclinical fatigue in the context of physical (pre-)frailty.",

keywords = "Aged, Community-dwelling, Fatigue, Handgrip, Muscle endurance, Pre-frailty, Vitality",

author = "{Gerontopole Brussels Study group} and Veerle Knoop and Axelle Costenoble and Aziz Debain and {Vella Azzopardi}, Roberta and Sofie Vermeiren and {van Laere}, Sven and Bart Jansen and Aldo Scafoglieri and Ivan Bautmans and Dominique Vert{\'e} and Ingo Beyer and Mirko Petrovic and {De Donder}, Liesbeth and Tinie Kardol and Gina Rossi and Peter Clarys and Erik Cattrysse and {de Hert}, Paul",

year = "2021",

month = sep,

doi = "10.1016/j.exger.2021.111440",

language = "English",

volume = "152",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

}

Gerontopole Brussels Study group, Knoop, V, Costenoble, A, Debain, A , Vella Azzopardi, R, Vermeiren, S, van Laere, S , Jansen, B , Scafoglieri, A , Bautmans, I , Verté, D , Beyer, I, Petrovic, M, De Donder, L, Kardol, T, Rossi, G , Clarys, P , Cattrysse, E & de Hert, P 2021, 'The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians', Experimental Gerontology, vol. 152, 111440. https://doi.org/10.1016/j.exger.2021.111440

TY - JOUR

T1 - The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians

AU - Gerontopole Brussels Study group

AU - Knoop, Veerle

AU - Costenoble, Axelle

AU - Debain, Aziz

AU - Vella Azzopardi, Roberta

AU - Vermeiren, Sofie

AU - van Laere, Sven

AU - Jansen, Bart

AU - Scafoglieri, Aldo

AU - Bautmans, Ivan

AU - Verté, Dominique

AU - Beyer, Ingo

AU - Petrovic, Mirko

AU - De Donder, Liesbeth

AU - Kardol, Tinie

AU - Rossi, Gina

AU - Clarys, Peter

AU - Cattrysse, Erik

AU - de Hert, Paul

PY - 2021/9

Y1 - 2021/9

N2 - Introduction: Low grip work and high feelings of self-perceived fatigue could be an early characteristic of decline in reserve capacity, which comes to full expression as physical frailty in a later stage. When grip work and self-perceived fatigue can be identified as characteristics differentiating between robustness and pre-frailty it might allow to identify pre-frailty earlier. Therefore, this study aimed to investigate whether the combination of grip work and self-perceived fatigue is related to pre-frailty in well-functioning older adults aged 80 and over. Methods: Four-hundred and five community-dwelling older adults aged 80 and over (214 robust and 191 pre-frail) were assessed for muscle endurance (grip Work corrected for body weight (GW_bw)), self-perceived fatigue (MFI-20) and frailty state (Fried Frailty Index, FFI). A Capacity to Perceived Vitality ratio (CPV) was calculated by dividing GW_bw by the MFI-20 scores. ANCOVA analysis (corrected for age and gender) was used to compare robust and pre-frail older adults, and binary logistic regressions were applied to analyze the relationship between CPV and pre-frailty status. Results: Pre-frail older adults who scored negative on the exhaustion item of the FFI still showed significantly lower GW (p < 0.001), CPV ratios (p < 0.001) and higher self-perceived fatigue (p < 0.05) compared to the robust ones. The likelihood for pre-frailty related significantly to higher age, being men and lower CPV ratios. In women, every unit increase in CPV ratio decreased the likelihood for pre-frailty by 78% (OR 0.22; 95% CI: 0.11–0.44), for men this effect was less strong (34%, OR 0.66; 95% CI: 0.47–0.93). Conclusions: Pre-frail community-dwelling persons aged 80 years and over without clinical signs of exhaustion on the FFI still experience significantly higher fatigue levels (lower Grip Work, higher self-perceived fatigue and lower CPV levels) compared to robust ones. CPV ratio could therefore be a good tool to identify subclinical fatigue in the context of physical (pre-)frailty.

AB - Introduction: Low grip work and high feelings of self-perceived fatigue could be an early characteristic of decline in reserve capacity, which comes to full expression as physical frailty in a later stage. When grip work and self-perceived fatigue can be identified as characteristics differentiating between robustness and pre-frailty it might allow to identify pre-frailty earlier. Therefore, this study aimed to investigate whether the combination of grip work and self-perceived fatigue is related to pre-frailty in well-functioning older adults aged 80 and over. Methods: Four-hundred and five community-dwelling older adults aged 80 and over (214 robust and 191 pre-frail) were assessed for muscle endurance (grip Work corrected for body weight (GW_bw)), self-perceived fatigue (MFI-20) and frailty state (Fried Frailty Index, FFI). A Capacity to Perceived Vitality ratio (CPV) was calculated by dividing GW_bw by the MFI-20 scores. ANCOVA analysis (corrected for age and gender) was used to compare robust and pre-frail older adults, and binary logistic regressions were applied to analyze the relationship between CPV and pre-frailty status. Results: Pre-frail older adults who scored negative on the exhaustion item of the FFI still showed significantly lower GW (p < 0.001), CPV ratios (p < 0.001) and higher self-perceived fatigue (p < 0.05) compared to the robust ones. The likelihood for pre-frailty related significantly to higher age, being men and lower CPV ratios. In women, every unit increase in CPV ratio decreased the likelihood for pre-frailty by 78% (OR 0.22; 95% CI: 0.11–0.44), for men this effect was less strong (34%, OR 0.66; 95% CI: 0.47–0.93). Conclusions: Pre-frail community-dwelling persons aged 80 years and over without clinical signs of exhaustion on the FFI still experience significantly higher fatigue levels (lower Grip Work, higher self-perceived fatigue and lower CPV levels) compared to robust ones. CPV ratio could therefore be a good tool to identify subclinical fatigue in the context of physical (pre-)frailty.

KW - Aged

KW - Community-dwelling

KW - Fatigue

KW - Handgrip

KW - Muscle endurance

KW - Pre-frailty

KW - Vitality

UR - http://www.scopus.com/inward/record.url?scp=85109525689&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2021.111440

DO - 10.1016/j.exger.2021.111440

M3 - Article

C2 - 34116174

AN - SCOPUS:85109525689

SN - 0531-5565

VL - 152

JO - Experimental Gerontology

JF - Experimental Gerontology

M1 - 111440

ER -

The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians

Abstract

Bibliographical note

Keywords

Access to Document

Handle.net

Other files and links

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IRP12: Interdisciplinary Research Program: Gerontopole Brussels, centre of expertise for Gerontology at the Vrije Universiteit Brussel

IRP3: The Gerontopole Brussels Centre of expertise of Gerontology at the Vrije Universiteit Brussel

Cite this

The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians

Abstract

Bibliographical note

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Projects

IRP12: Interdisciplinary Research Program: Gerontopole Brussels, centre of expertise for Gerontology at the Vrije Universiteit Brussel

IRP3: The Gerontopole Brussels Centre of expertise of Gerontology at the Vrije Universiteit Brussel

Cite this