The microenvironment and molecular biology of the multiple myeloma tumor

Miguel Lemaire, Sarah Deleu, Elke De Bruyne, Els Van Valckenborgh, Eline Menu, Karin Vanderkerken

Research output: Chapter in Book/Report/Conference proceedingChapter

54 Citations (Scopus)

Abstract

Multiple myeloma (MM) is a deadly plasma cell cancer that resides in the bone marrow (BM). Numerous studies have demonstrated the involvement of the BM microenvironment supporting tumor growth, angiogenesis, bone disease and drug resistance. Reciprocal interactions between the different components of the BM microenvironment and the MM cells are necessary to regulate migration, differentiation, proliferation and survival of the malignant plasma cells. In this review we focus on the interactions and molecular mechanisms by which the BM microenvironment exert these effects. Better understanding of these interactions and the study of the epigenetic changes that tumor cells undergo are necessary in order to improve current treatments and for the discovery of new therapies that may eventually lead to a potential cure.
Original languageEnglish
Title of host publicationAdvances in Cancer Research
EditorsGeorge Vande Woude, George Klein
PublisherAcademic Press
Pages19-42
Number of pages24
ISBN (Electronic)9780123864703
ISBN (Print)9780123864697
Publication statusPublished - 15 Apr 2011

Publication series

NameAdvances in Cancer Research
PublisherAcademic Press
Volume110
ISSN (Print)0065-230X

Keywords

  • multiple myeolma
  • microenvironment
  • molecular biology

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