The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

Kirsten Kubler; Rosa Karlic; Nicholas J. Haradhvala; Kyungsik Ha; Jaegil Kim; Maja Kuzman; Wei Jiao; Sitanshu Gakkhar; Kent W. Mouw; Lior Z. Braunstein; Olivier Elemento; Andrew V. Biankin; Ilse Rooman; Mendy Miller; Christopher D. Nogiec; Edward Curry; Mari Mino-Kenudson; Leif W. Ellisen; Robert Brown; Alexander Gusev; Cristian Tomasetti; Hong-Gee Kim; Hwajin Lee; Kristian Vlahovicek; Charles Sawyers; Katherine A. Hoadley; Edwin Cuppen; Amnon Koren; Peter F. Arndt; David N. Louis; Lincoln Stein; William D. Foulkes; Paz Polak; Gad Getz

doi:10.1158/1538-7445.AM2019-2727

The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

Kirsten Kubler, Rosa Karlic, Nicholas J. Haradhvala, Kyungsik Ha, Jaegil Kim, Maja Kuzman, Wei Jiao, Sitanshu Gakkhar, Kent W. Mouw, Lior Z. Braunstein, Olivier Elemento, Andrew V. Biankin, Ilse Rooman, Mendy Miller, Christopher D. Nogiec, Edward Curry, Mari Mino-Kenudson, Leif W. Ellisen, Robert Brown, Alexander GusevCristian Tomasetti, Hong-Gee Kim, Hwajin Lee, Kristian Vlahovicek, Charles Sawyers, Katherine A. Hoadley, Edwin Cuppen, Amnon Koren, Peter F. Arndt, David N. Louis, Lincoln Stein, William D. Foulkes, Paz Polak, Gad Getz

Research output: Contribution to journal › Meeting abstract (Journal)

Original language	English
Article number	2727
Journal	Cancer Research
Volume	79
Issue number	13
DOIs	https://doi.org/10.1158/1538-7445.AM2019-2727
Publication status	Published - Jul 2019
Event	Annual Meeting of the American-Association-for-Cancer-Research (AACR) - Atlanta, United States Duration: 29 Mar 2019 → 3 Apr 2019

Keywords

cancer cell
premalignant state
somatic mutations

Access to Document

10.1158/1538-7445.AM2019-2727

FWOODYS12: De-convolution of tumour biology in the post-genomic era: focus on pancreatic cancer
Rooman, I.
1/10/16 → 1/10/21
Project: Fundamental

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Kubler, K., Karlic, R., Haradhvala, N. J., Ha, K., Kim, J., Kuzman, M., Jiao, W., Gakkhar, S., Mouw, K. W., Braunstein, L. Z., Elemento, O., Biankin, A. V., Rooman, I., Miller, M., Nogiec, C. D., Curry, E., Mino-Kenudson, M., Ellisen, L. W., Brown, R., ... Getz, G. (2019). The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin. Cancer Research, 79(13), [2727]. https://doi.org/10.1158/1538-7445.AM2019-2727

Kubler, Kirsten ; Karlic, Rosa ; Haradhvala, Nicholas J. ; Ha, Kyungsik ; Kim, Jaegil ; Kuzman, Maja ; Jiao, Wei ; Gakkhar, Sitanshu ; Mouw, Kent W. ; Braunstein, Lior Z. ; Elemento, Olivier ; Biankin, Andrew V. ; Rooman, Ilse ; Miller, Mendy ; Nogiec, Christopher D. ; Curry, Edward ; Mino-Kenudson, Mari ; Ellisen, Leif W. ; Brown, Robert ; Gusev, Alexander ; Tomasetti, Cristian ; Kim, Hong-Gee ; Lee, Hwajin ; Vlahovicek, Kristian ; Sawyers, Charles ; Hoadley, Katherine A. ; Cuppen, Edwin ; Koren, Amnon ; Arndt, Peter F. ; Louis, David N. ; Stein, Lincoln ; Foulkes, William D. ; Polak, Paz ; Getz, Gad. / The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin. In: Cancer Research. 2019 ; Vol. 79, No. 13.

@article{47304ec4ff1f4f8ca3072b4fd500bc05,

title = "The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin",

keywords = "cancer cell, premalignant state, somatic mutations",

author = "Kirsten Kubler and Rosa Karlic and Haradhvala, {Nicholas J.} and Kyungsik Ha and Jaegil Kim and Maja Kuzman and Wei Jiao and Sitanshu Gakkhar and Mouw, {Kent W.} and Braunstein, {Lior Z.} and Olivier Elemento and Biankin, {Andrew V.} and Ilse Rooman and Mendy Miller and Nogiec, {Christopher D.} and Edward Curry and Mari Mino-Kenudson and Ellisen, {Leif W.} and Robert Brown and Alexander Gusev and Cristian Tomasetti and Hong-Gee Kim and Hwajin Lee and Kristian Vlahovicek and Charles Sawyers and Hoadley, {Katherine A.} and Edwin Cuppen and Amnon Koren and Arndt, {Peter F.} and Louis, {David N.} and Lincoln Stein and Foulkes, {William D.} and Paz Polak and Gad Getz",

year = "2019",

month = jul,

doi = "10.1158/1538-7445.AM2019-2727",

language = "English",

volume = "79",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "13",

note = "Annual Meeting of the American-Association-for-Cancer-Research (AACR) ; Conference date: 29-03-2019 Through 03-04-2019",

}

Kubler, K, Karlic, R, Haradhvala, NJ, Ha, K, Kim, J, Kuzman, M, Jiao, W, Gakkhar, S, Mouw, KW, Braunstein, LZ, Elemento, O, Biankin, AV, Rooman, I, Miller, M, Nogiec, CD, Curry, E, Mino-Kenudson, M, Ellisen, LW, Brown, R, Gusev, A, Tomasetti, C, Kim, H-G, Lee, H, Vlahovicek, K, Sawyers, C, Hoadley, KA, Cuppen, E, Koren, A, Arndt, PF, Louis, DN, Stein, L, Foulkes, WD, Polak, P & Getz, G 2019, 'The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin', Cancer Research, vol. 79, no. 13, 2727. https://doi.org/10.1158/1538-7445.AM2019-2727

The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin. / Kubler, Kirsten; Karlic, Rosa; Haradhvala, Nicholas J.; Ha, Kyungsik; Kim, Jaegil; Kuzman, Maja; Jiao, Wei; Gakkhar, Sitanshu; Mouw, Kent W.; Braunstein, Lior Z.; Elemento, Olivier; Biankin, Andrew V.; Rooman, Ilse; Miller, Mendy; Nogiec, Christopher D.; Curry, Edward; Mino-Kenudson, Mari; Ellisen, Leif W.; Brown, Robert; Gusev, Alexander; Tomasetti, Cristian; Kim, Hong-Gee; Lee, Hwajin; Vlahovicek, Kristian; Sawyers, Charles; Hoadley, Katherine A.; Cuppen, Edwin; Koren, Amnon; Arndt, Peter F.; Louis, David N.; Stein, Lincoln; Foulkes, William D.; Polak, Paz; Getz, Gad.

In: Cancer Research, Vol. 79, No. 13, 2727, 07.2019.

Research output: Contribution to journal › Meeting abstract (Journal)

TY - JOUR

T1 - The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

AU - Kubler, Kirsten

AU - Karlic, Rosa

AU - Haradhvala, Nicholas J.

AU - Ha, Kyungsik

AU - Kim, Jaegil

AU - Kuzman, Maja

AU - Jiao, Wei

AU - Gakkhar, Sitanshu

AU - Mouw, Kent W.

AU - Braunstein, Lior Z.

AU - Elemento, Olivier

AU - Biankin, Andrew V.

AU - Rooman, Ilse

AU - Miller, Mendy

AU - Nogiec, Christopher D.

AU - Curry, Edward

AU - Mino-Kenudson, Mari

AU - Ellisen, Leif W.

AU - Brown, Robert

AU - Gusev, Alexander

AU - Tomasetti, Cristian

AU - Kim, Hong-Gee

AU - Lee, Hwajin

AU - Vlahovicek, Kristian

AU - Sawyers, Charles

AU - Hoadley, Katherine A.

AU - Cuppen, Edwin

AU - Koren, Amnon

AU - Arndt, Peter F.

AU - Louis, David N.

AU - Stein, Lincoln

AU - Foulkes, William D.

AU - Polak, Paz

AU - Getz, Gad

PY - 2019/7

Y1 - 2019/7

KW - cancer cell

KW - premalignant state

KW - somatic mutations

U2 - 10.1158/1538-7445.AM2019-2727

DO - 10.1158/1538-7445.AM2019-2727

M3 - Meeting abstract (Journal)

VL - 79

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 13

M1 - 2727

T2 - Annual Meeting of the American-Association-for-Cancer-Research (AACR)

Y2 - 29 March 2019 through 3 April 2019

ER -

The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

Keywords

Access to Document

Projects

FWOODYS12: De-convolution of tumour biology in the post-genomic era: focus on pancreatic cancer

Cite this