The Role of Functional Amyloids in Bacterial Virulence

Nani Van Gerven, Sander E Van der Verren, Dirk M Reiter, Han Remaut

Research output: Contribution to journalScientific reviewpeer-review

89 Citations (Scopus)

Abstract

Amyloid fibrils are best known as a product of human and animal protein misfolding disorders, where amyloid formation is associated with cytotoxicity and disease. It is now evident that for some proteins, the amyloid state constitutes the native structure and serves a functional role. These functional amyloids are proving widespread in bacteria and fungi, fulfilling diverse functions as structural components in biofilms or spore coats, as toxins and surface-active fibers, as epigenetic material, peptide reservoirs or adhesins mediating binding to and internalization into host cells. In this review, we will focus on the role of functional amyloids in bacterial pathogenesis. The role of functional amyloids as virulence factor is diverse but mostly indirect. Nevertheless, functional amyloid pathways deserve consideration for the acute and long-term effects of the infectious disease process and may form valid antimicrobial targets.

Original languageEnglish
Pages (from-to)3657-3684
Number of pages28
JournalJournal of Molecular Biology
Volume430
Issue number20
Early online date12 Jul 2018
DOIs
Publication statusPublished - 12 Oct 2018

Keywords

  • amyloid
  • bacterial adhesion
  • bacterial pathogenesis
  • biofilm
  • curli

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