The role of progesterone elevation in IVF

Panagiotis Drakopoulos, Annalisa Racca, Joaquín Errázuriz, Michel De Vos, Herman Tournaye, Christophe Blockeel, Nicola Pluchino, Samuel Santos-Ribeiro

Research output: Contribution to journalScientific reviewpeer-review

15 Citations (Scopus)


Elevation of progesterone during the late follicular phase of stimulated in-vitro fertilization cycles is a frequent event, which negatively impacts the outcome. Over the years evidence has demonstrated a direct relationship between late-follicular elevated progesterone and endometrial receptivity. In this regard, elective cryopreservation of all good quality embryos and transfer in a subsequent frozen/thawed cycle is the most common strategy adopted by clinicians in case of elevated progesterone. Nonetheless, recent evidence suggests that elective cryopreservation might not entirely resolve the reduced pregnancy outcomes associated with the elevation of progesterone, considering that the increase may affect not only implantation, but also embryo quality.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalReproductive biology
Issue number1
Publication statusPublished - Mar 2019

Bibliographical note

Copyright © 2019 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.


  • Embryo quality
  • Endometrial receptivity
  • Implantation
  • In vitro fertilization
  • Progesterone elevation


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