The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

Kirsten Aigner; Luise Descovich; Mario Mikula; Aneesa Sultan; Dampier Brigitta; Stefan Bonne; Frans Van Roy; Wolfgang Mikulits; Martin Schreiber; Thomas Brabletz; Wolfgang Sommergruber; Norbert Schweifer; Andreas Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

Kirsten Aigner, Luise Descovich, Mario Mikula, Aneesa Sultan, Dampier Brigitta, Stefan Bonne, Frans Van Roy, Wolfgang Mikulits, Martin Schreiber, Thomas Brabletz, Wolfgang Sommergruber, Norbert Schweifer, Andreas Wernitznig, Hartmut Beug, Roland Foisner, Andreas Eger

Pathologic Biochemistry and Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Plakophilin 3 (PKP3) belongs to the p120ctn family
of armadillo-related proteins predominantly functioning in desmosome
formation. Here we report that PKP3 is transcriptionally
repressed by the E-cadherin repressor ZEB1 in metastatic
cancer cells. ZEB1 physically associates with two conserved Ebox
elements in the PKP3 promoter and partially represses the
activity of corresponding human and mouse PKP3 promoter
fragments in reporter gene assays. In human tumours ZEB1 is
upregulated in invasive cancer cells at the tumour/host interface,
which is accompanied by downregulation of PKP3 expression
levels. Hence, the transcriptional repression of PKP3 by ZEB1
contributes to ZEB1-mediated disintegration of intercellular
adhesion and epithelial to mesenchymal transition.

Original language	English
Pages (from-to)	1617-1624
Number of pages	8
Journal	FEBS Letters
Volume	8
Issue number	581
Publication status	Published - 21 Mar 2007

Keywords

Epithelial to mesenchymal transition; Invasion;

Unknown (External organisation)
Stefan Bonne (Member)
1 Jul 2003 → …
Activity: Membership › Membership of external research organisation

Cite this

Aigner, Kirsten ; Descovich, Luise ; Mikula, Mario ; Sultan, Aneesa ; Brigitta, Dampier ; Bonne, Stefan ; Van Roy, Frans ; Mikulits, Wolfgang ; Schreiber, Martin ; Brabletz, Thomas ; Sommergruber, Wolfgang ; Schweifer, Norbert ; Wernitznig, Andreas ; Beug, Hartmut ; Foisner, Roland ; Eger, Andreas. / The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. In: FEBS Letters. 2007 ; Vol. 8, No. 581. pp. 1617-1624.

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title = "The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression",

abstract = "Abstract Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved Ebox elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour/host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.",

keywords = "Epithelial to mesenchymal transition; Invasion;",

author = "Kirsten Aigner and Luise Descovich and Mario Mikula and Aneesa Sultan and Dampier Brigitta and Stefan Bonne and {Van Roy}, Frans and Wolfgang Mikulits and Martin Schreiber and Thomas Brabletz and Wolfgang Sommergruber and Norbert Schweifer and Andreas Wernitznig and Hartmut Beug and Roland Foisner and Andreas Eger",

year = "2007",

month = mar,

day = "21",

language = "English",

volume = "8",

pages = "1617--1624",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "581",

}

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. / Aigner, Kirsten; Descovich, Luise; Mikula, Mario; Sultan, Aneesa; Brigitta, Dampier; Bonne, Stefan; Van Roy, Frans; Mikulits, Wolfgang; Schreiber, Martin; Brabletz, Thomas; Sommergruber, Wolfgang; Schweifer, Norbert; Wernitznig, Andreas; Beug, Hartmut; Foisner, Roland; Eger, Andreas.

In: FEBS Letters, Vol. 8, No. 581, 21.03.2007, p. 1617-1624.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

AU - Aigner, Kirsten

AU - Descovich, Luise

AU - Mikula, Mario

AU - Sultan, Aneesa

AU - Brigitta, Dampier

AU - Bonne, Stefan

AU - Van Roy, Frans

AU - Mikulits, Wolfgang

AU - Schreiber, Martin

AU - Brabletz, Thomas

AU - Sommergruber, Wolfgang

AU - Schweifer, Norbert

AU - Wernitznig, Andreas

AU - Beug, Hartmut

AU - Foisner, Roland

AU - Eger, Andreas

PY - 2007/3/21

Y1 - 2007/3/21

N2 - Abstract Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved Ebox elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour/host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.

AB - Abstract Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved Ebox elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour/host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.

KW - Epithelial to mesenchymal transition; Invasion;

M3 - Article

VL - 8

SP - 1617

EP - 1624

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 581

ER -

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

Abstract

Keywords

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