The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder

Stephen V Faraone; Tobias Banaschewski; David Coghill; Yi Zheng; Joseph Biederman; Mark A Bellgrove; Jeffrey H Newcorn; Martin Gignac; Nouf M Al Saud; Iris Manor; Luis Augusto Rohde; Li Yang; Samuele Cortese; Doron Almagor; Mark A Stein; Turki H Albatti; Haya F Aljoudi; Mohammed M J Alqahtani; Philip Asherson; Lukoye Atwoli; Sven Bölte; Jan K Buitelaar; Cleo L Crunelle; David Daley; Søren Dalsgaard; Manfred Döepfner; Stacey Espinet; Michael Fitzgerald; Barbara Franke; Jan Haavik; Catharina A Hartman; Cynthia M Hartung; Stephen P Hinshaw; Pieter J Hoekstra; Chris Hollis; Scott H Kollins; J J Sandra Kooij; Jonna Kuntsi; Henrik Larsson; Tingyu Li; Jing Liu; Eugene Merzon; Gregory Mattingly; Paulo Mattos; Suzanne McCarthy; Amori Yee Mikami; Brooke S G Molina; Joel T Nigg; Diane Purper-Ouakil; Olayinka O Omigbodun; Guilherme V Polanczyk; Yehuda Pollak; Alison S Poulton; Ravi Philip Rajkumar; Andrew Reding; Andreas Reif; Katya Rubia; Julia Rucklidge; Marcel Romanos; J Antoni Ramos-Quiroga; Arnt Schellekens; Anouk Scheres; Renata Schoeman; Julie B Schweitzer; Henal Shah; Mary V Solanto; Edmund Sonuga-Barke; César Soutullo; Hans-Christoph Steinhausen; James M Swanson; Anita Thapar; Gail Tripp; Geurt van de Glind; Wim van den Brink; Saskia Van der Oord; Andre Venter; Benedetto Vitiello; Susanne Walitza; Yufeng Wang

doi:10.1016/j.neubiorev.2021.01.022

The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder

Stephen V Faraone
, Tobias Banaschewski
, David Coghill
, Yi Zheng
, Joseph Biederman
, Mark A Bellgrove
, Jeffrey H Newcorn
, Martin Gignac
, Nouf M Al Saud
, Iris Manor
, Luis Augusto Rohde
, Li Yang
, Samuele Cortese
, Doron Almagor
, Mark A Stein
, Turki H Albatti
, Haya F Aljoudi
, Mohammed M J Alqahtani
, Philip Asherson
, Lukoye Atwoli

Sven Bölte, Jan K Buitelaar, Cleo L Crunelle, David Daley, Søren Dalsgaard, Manfred Döepfner, Stacey Espinet, Michael Fitzgerald, Barbara Franke, Jan Haavik, Catharina A Hartman, Cynthia M Hartung, Stephen P Hinshaw, Pieter J Hoekstra, Chris Hollis, Scott H Kollins, J J Sandra Kooij, Jonna Kuntsi, Henrik Larsson, Tingyu Li, Jing Liu, Eugene Merzon, Gregory Mattingly, Paulo Mattos, Suzanne McCarthy, Amori Yee Mikami, Brooke S G Molina, Joel T Nigg, Diane Purper-Ouakil, Olayinka O Omigbodun, Guilherme V Polanczyk, Yehuda Pollak, Alison S Poulton, Ravi Philip Rajkumar, Andrew Reding, Andreas Reif, Katya Rubia, Julia Rucklidge, Marcel Romanos, J Antoni Ramos-Quiroga, Arnt Schellekens, Anouk Scheres, Renata Schoeman, Julie B Schweitzer, Henal Shah, Mary V Solanto, Edmund Sonuga-Barke, César Soutullo, Hans-Christoph Steinhausen, James M Swanson, Anita Thapar, Gail Tripp, Geurt van de Glind, Wim van den Brink, Saskia Van der Oord, Andre Venter, Benedetto Vitiello, Susanne Walitza, Yufeng Wang

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.

METHODS: We reviewed studies with more than 2,000 participants or meta-analyses from five or more studies or 2,000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.

RESULTS: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 79 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 362 people who have read this document and agree with its contents.

CONCLUSIONS: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.

Original language	English
Pages (from-to)	789-818
Number of pages	30
Journal	Neuroscience and Biobehavioral Reviews
Volume	128
Early online date	4 Feb 2021
DOIs	https://doi.org/10.1016/j.neubiorev.2021.01.022
Publication status	Published - Sept 2021

Bibliographical note

Keywords

ADHD
brain
diagnosis
genetics
outcome
treatment

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Faraone, S. V., Banaschewski, T., Coghill, D., Zheng, Y., Biederman, J., Bellgrove, M. A., Newcorn, J. H., Gignac, M., Al Saud, N. M., Manor, I., Rohde, L. A., Yang, L., Cortese, S., Almagor, D., Stein, M. A., Albatti, T. H., Aljoudi, H. F., Alqahtani, M. M. J., Asherson, P., ... Wang, Y. (2021). The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder. Neuroscience and Biobehavioral Reviews, 128, 789-818. https://doi.org/10.1016/j.neubiorev.2021.01.022

@article{dfb607550bf947a485b6f2c0a789247a,

title = "The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder",

abstract = "BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.METHODS: We reviewed studies with more than 2,000 participants or meta-analyses from five or more studies or 2,000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.RESULTS: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 79 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 362 people who have read this document and agree with its contents.CONCLUSIONS: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.",

keywords = "ADHD, brain, diagnosis, genetics, outcome, treatment",

author = "Faraone, \{Stephen V\} and Tobias Banaschewski and David Coghill and Yi Zheng and Joseph Biederman and Bellgrove, \{Mark A\} and Newcorn, \{Jeffrey H\} and Martin Gignac and \{Al Saud\}, \{Nouf M\} and Iris Manor and Rohde, \{Luis Augusto\} and Li Yang and Samuele Cortese and Doron Almagor and Stein, \{Mark A\} and Albatti, \{Turki H\} and Aljoudi, \{Haya F\} and Alqahtani, \{Mohammed M J\} and Philip Asherson and Lukoye Atwoli and Sven B{\"o}lte and Buitelaar, \{Jan K\} and Crunelle, \{Cleo L\} and David Daley and S{\o}ren Dalsgaard and Manfred D{\"o}epfner and Stacey Espinet and Michael Fitzgerald and Barbara Franke and Jan Haavik and Hartman, \{Catharina A\} and Hartung, \{Cynthia M\} and Hinshaw, \{Stephen P\} and Hoekstra, \{Pieter J\} and Chris Hollis and Kollins, \{Scott H\} and \{Sandra Kooij\}, \{J J\} and Jonna Kuntsi and Henrik Larsson and Tingyu Li and Jing Liu and Eugene Merzon and Gregory Mattingly and Paulo Mattos and Suzanne McCarthy and Mikami, \{Amori Yee\} and Molina, \{Brooke S G\} and Nigg, \{Joel T\} and Diane Purper-Ouakil and Omigbodun, \{Olayinka O\} and Polanczyk, \{Guilherme V\} and Yehuda Pollak and Poulton, \{Alison S\} and Rajkumar, \{Ravi Philip\} and Andrew Reding and Andreas Reif and Katya Rubia and Julia Rucklidge and Marcel Romanos and Ramos-Quiroga, \{J Antoni\} and Arnt Schellekens and Anouk Scheres and Renata Schoeman and Schweitzer, \{Julie B\} and Henal Shah and Solanto, \{Mary V\} and Edmund Sonuga-Barke and C{\'e}sar Soutullo and Hans-Christoph Steinhausen and Swanson, \{James M\} and Anita Thapar and Gail Tripp and \{van de Glind\}, Geurt and Brink, \{Wim van den\} and \{Van der Oord\}, Saskia and Andre Venter and Benedetto Vitiello and Susanne Walitza and Yufeng Wang",

note = "Copyright {\textcopyright} 2021. Published by Elsevier Ltd.",

year = "2021",

month = sep,

doi = "10.1016/j.neubiorev.2021.01.022",

language = "English",

volume = "128",

pages = "789--818",

journal = "Neuroscience and Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Limited",

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Faraone, SV, Banaschewski, T, Coghill, D, Zheng, Y, Biederman, J, Bellgrove, MA, Newcorn, JH, Gignac, M, Al Saud, NM, Manor, I, Rohde, LA, Yang, L, Cortese, S, Almagor, D, Stein, MA, Albatti, TH, Aljoudi, HF, Alqahtani, MMJ, Asherson, P, Atwoli, L, Bölte, S, Buitelaar, JK, Crunelle, CL, Daley, D, Dalsgaard, S, Döepfner, M, Espinet, S, Fitzgerald, M, Franke, B, Haavik, J, Hartman, CA, Hartung, CM, Hinshaw, SP, Hoekstra, PJ, Hollis, C, Kollins, SH, Sandra Kooij, JJ, Kuntsi, J, Larsson, H, Li, T, Liu, J, Merzon, E, Mattingly, G, Mattos, P, McCarthy, S, Mikami, AY, Molina, BSG, Nigg, JT, Purper-Ouakil, D, Omigbodun, OO, Polanczyk, GV, Pollak, Y, Poulton, AS, Rajkumar, RP, Reding, A, Reif, A, Rubia, K, Rucklidge, J, Romanos, M, Ramos-Quiroga, JA, Schellekens, A, Scheres, A, Schoeman, R, Schweitzer, JB, Shah, H, Solanto, MV, Sonuga-Barke, E, Soutullo, C, Steinhausen, H-C, Swanson, JM, Thapar, A, Tripp, G, van de Glind, G, Brink, WVD, Van der Oord, S, Venter, A, Vitiello, B, Walitza, S & Wang, Y 2021, 'The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder', Neuroscience and Biobehavioral Reviews, vol. 128, pp. 789-818. https://doi.org/10.1016/j.neubiorev.2021.01.022

TY - JOUR

T1 - The World Federation of ADHD International Consensus Statement

T2 - 208 Evidence-based Conclusions about the Disorder

AU - Faraone, Stephen V

AU - Banaschewski, Tobias

AU - Coghill, David

AU - Zheng, Yi

AU - Biederman, Joseph

AU - Bellgrove, Mark A

AU - Newcorn, Jeffrey H

AU - Gignac, Martin

AU - Al Saud, Nouf M

AU - Manor, Iris

AU - Rohde, Luis Augusto

AU - Yang, Li

AU - Cortese, Samuele

AU - Almagor, Doron

AU - Stein, Mark A

AU - Albatti, Turki H

AU - Aljoudi, Haya F

AU - Alqahtani, Mohammed M J

AU - Asherson, Philip

AU - Atwoli, Lukoye

AU - Bölte, Sven

AU - Buitelaar, Jan K

AU - Crunelle, Cleo L

AU - Daley, David

AU - Dalsgaard, Søren

AU - Döepfner, Manfred

AU - Espinet, Stacey

AU - Fitzgerald, Michael

AU - Franke, Barbara

AU - Haavik, Jan

AU - Hartman, Catharina A

AU - Hartung, Cynthia M

AU - Hinshaw, Stephen P

AU - Hoekstra, Pieter J

AU - Hollis, Chris

AU - Kollins, Scott H

AU - Sandra Kooij, J J

AU - Kuntsi, Jonna

AU - Larsson, Henrik

AU - Li, Tingyu

AU - Liu, Jing

AU - Merzon, Eugene

AU - Mattingly, Gregory

AU - Mattos, Paulo

AU - McCarthy, Suzanne

AU - Mikami, Amori Yee

AU - Molina, Brooke S G

AU - Nigg, Joel T

AU - Purper-Ouakil, Diane

AU - Omigbodun, Olayinka O

AU - Polanczyk, Guilherme V

AU - Pollak, Yehuda

AU - Poulton, Alison S

AU - Rajkumar, Ravi Philip

AU - Reding, Andrew

AU - Reif, Andreas

AU - Rubia, Katya

AU - Rucklidge, Julia

AU - Romanos, Marcel

AU - Ramos-Quiroga, J Antoni

AU - Schellekens, Arnt

AU - Scheres, Anouk

AU - Schoeman, Renata

AU - Schweitzer, Julie B

AU - Shah, Henal

AU - Solanto, Mary V

AU - Sonuga-Barke, Edmund

AU - Soutullo, César

AU - Steinhausen, Hans-Christoph

AU - Swanson, James M

AU - Thapar, Anita

AU - Tripp, Gail

AU - van de Glind, Geurt

AU - Brink, Wim van den

AU - Van der Oord, Saskia

AU - Venter, Andre

AU - Vitiello, Benedetto

AU - Walitza, Susanne

AU - Wang, Yufeng

PY - 2021/9

Y1 - 2021/9

N2 - BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.METHODS: We reviewed studies with more than 2,000 participants or meta-analyses from five or more studies or 2,000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.RESULTS: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 79 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 362 people who have read this document and agree with its contents.CONCLUSIONS: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.

AB - BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.METHODS: We reviewed studies with more than 2,000 participants or meta-analyses from five or more studies or 2,000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.RESULTS: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 79 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 362 people who have read this document and agree with its contents.CONCLUSIONS: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.

KW - ADHD

KW - brain

KW - diagnosis

KW - genetics

KW - outcome

KW - treatment

UR - https://www.scopus.com/pages/publications/85103736896

U2 - 10.1016/j.neubiorev.2021.01.022

DO - 10.1016/j.neubiorev.2021.01.022

M3 - Article

C2 - 33549739

SN - 0149-7634

VL - 128

SP - 789

EP - 818

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder

Abstract

Bibliographical note

Keywords

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