Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation

Lidia Ghisdal; Nilufer Broeders; Karl Martin Wissing; J Mbaba Mena; Anne Lemy; Walter Wijns; Oliver Pradier; Vincent Donckier; Judith Racape; Pierre Vereertstraeten; Daniel Abramowicz

Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation

Lidia Ghisdal, Nilufer Broeders, Karl Martin Wissing, J Mbaba Mena, Anne Lemy, Walter Wijns, Oliver Pradier, Vincent Donckier, Judith Racape, Pierre Vereertstraeten, Daniel Abramowicz

Internal Medicine Specializations

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background. The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year.

Methods. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation.

Results. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P
Conclusion. Acquired thrombophilic factors are highly prevalent among Stage V CKD patients. Most thrombophilic factors are corrected 1 month after transplantation.

Original language	English
Pages (from-to)	2700-2705
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	26
Issue number	AUG
Publication status	Published - Aug 2011

Keywords

coagulation
haemodialysis
renal transplantation
thrombophilia

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Ghisdal, L., Broeders, N., Wissing, K. M., Mena, J. M., Lemy, A., Wijns, W., Pradier, O., Donckier, V., Racape, J., Vereertstraeten, P., & Abramowicz, D. (2011). Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation. Nephrology Dialysis Transplantation, 26(AUG), 2700-2705. http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=3E8oe@oO@c13D1c3gl9&page=1&doc=3

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title = "Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation",

abstract = "Background. The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year. Methods. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation. Results. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P Conclusion. Acquired thrombophilic factors are highly prevalent among Stage V CKD patients. Most thrombophilic factors are corrected 1 month after transplantation.",

keywords = "coagulation, haemodialysis, renal transplantation, thrombophilia",

author = "Lidia Ghisdal and Nilufer Broeders and Wissing, {Karl Martin} and Mena, {J Mbaba} and Anne Lemy and Walter Wijns and Oliver Pradier and Vincent Donckier and Judith Racape and Pierre Vereertstraeten and Daniel Abramowicz",

year = "2011",

month = aug,

language = "English",

volume = "26",

pages = "2700--2705",

journal = "Nephrology Dialysis Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

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Ghisdal, L, Broeders, N, Wissing, KM, Mena, JM, Lemy, A, Wijns, W, Pradier, O, Donckier, V, Racape, J, Vereertstraeten, P & Abramowicz, D 2011, 'Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation', Nephrology Dialysis Transplantation, vol. 26, no. AUG, pp. 2700-2705. <http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=3E8oe@oO@c13D1c3gl9&page=1&doc=3>

TY - JOUR

T1 - Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation

AU - Ghisdal, Lidia

AU - Broeders, Nilufer

AU - Wissing, Karl Martin

AU - Mena, J Mbaba

AU - Lemy, Anne

AU - Wijns, Walter

AU - Pradier, Oliver

AU - Donckier, Vincent

AU - Racape, Judith

AU - Vereertstraeten, Pierre

AU - Abramowicz, Daniel

PY - 2011/8

Y1 - 2011/8

N2 - Background. The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year. Methods. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation. Results. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P Conclusion. Acquired thrombophilic factors are highly prevalent among Stage V CKD patients. Most thrombophilic factors are corrected 1 month after transplantation.

AB - Background. The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year. Methods. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation. Results. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P Conclusion. Acquired thrombophilic factors are highly prevalent among Stage V CKD patients. Most thrombophilic factors are corrected 1 month after transplantation.

KW - coagulation

KW - haemodialysis

KW - renal transplantation

KW - thrombophilia

M3 - Article

SN - 0931-0509

VL - 26

SP - 2700

EP - 2705

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

IS - AUG

ER -

Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation

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