Thymosin {beta}4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.

Jo Caers, D. Hose, Ine Kuipers, Tomas Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Benjamin Van Camp, Bernard Klein, Karin Vanderkerken

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Thymosin beta 4 (Tbeta4) is a polypeptide involved in cellular proliferation, differentiation, and migration, overexpressed in several tumor-entities. We evaluated its expression and function in 298 newly diagnosed multiple-myeloma patients and the murine 5TMM model. Mean-Tbeta4-expression was significantly lower in myeloma cells compared to normal plasma cells (p
Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalHaematologica
Volume95
Early online date14 Oct 2009
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Thymosin beta 4
  • myeloma
  • the murine 5TMM model

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