Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

Inneke Willekens; Tony Lahoutte; Nico Buls; Christian Vanhove; Rudi Deklerck; Axel Bossuyt; Johan de Mey

doi:10.1007/s11307-008-0186-8

Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

Inneke Willekens, Tony Lahoutte, Nico Buls, Christian Vanhove, Rudi Deklerck, Axel Bossuyt, Johan de Mey

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.

PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.

RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.

CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

Original language	English
Pages (from-to)	128-135
Number of pages	8
Journal	Mol Imaging Biol
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/s11307-008-0186-8
Publication status	Published - 11 Dec 2008

Keywords

Animals
Contrast Media
Image Processing, Computer-Assisted
Liver
Male
Metabolic Clearance Rate
Mice
Mice, Inbred C57BL
Nonlinear Dynamics
Spleen
Time Factors
X-Ray Microtomography

Access to Document

10.1007/s11307-008-0186-8

Cite this

@article{dd2acf31555d41c0b4f499710aa8cfc2,

title = "Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC",

abstract = "OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.",

keywords = "Animals, Contrast Media, Image Processing, Computer-Assisted, Liver, Male, Metabolic Clearance Rate, Mice, Mice, Inbred C57BL, Nonlinear Dynamics, Spleen, Time Factors, X-Ray Microtomography",

author = "Inneke Willekens and Tony Lahoutte and Nico Buls and Christian Vanhove and Rudi Deklerck and Axel Bossuyt and {de Mey}, Johan",

year = "2008",

month = dec,

day = "11",

doi = "10.1007/s11307-008-0186-8",

language = "English",

volume = "11",

pages = "128--135",

journal = "Mol Imaging Biol",

issn = "1536-1632",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

AU - Willekens, Inneke

AU - Lahoutte, Tony

AU - Buls, Nico

AU - Vanhove, Christian

AU - Deklerck, Rudi

AU - Bossuyt, Axel

AU - de Mey, Johan

PY - 2008/12/11

Y1 - 2008/12/11

N2 - OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

AB - OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

KW - Animals

KW - Contrast Media

KW - Image Processing, Computer-Assisted

KW - Liver

KW - Male

KW - Metabolic Clearance Rate

KW - Mice

KW - Mice, Inbred C57BL

KW - Nonlinear Dynamics

KW - Spleen

KW - Time Factors

KW - X-Ray Microtomography

U2 - 10.1007/s11307-008-0186-8

DO - 10.1007/s11307-008-0186-8

M3 - Article

C2 - 19067081

SN - 1536-1632

VL - 11

SP - 128

EP - 135

JO - Mol Imaging Biol

JF - Mol Imaging Biol

IS - 2

ER -

Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

Abstract

Keywords

Access to Document

Fingerprint

Cite this