TNFRSF1A coding variants in multiple sclerosis

An Goris, Niels Fockaert, Leentje Cosemans, Katleen Clysters, Guy Nagels, Steven Boonen, Vincent Thijs, Wim Robberecht, Benedicte Dubois

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5 x 10(-4), 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed.
Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalJournal of Neuroimmunology
Publication statusPublished - Jun 2011


  • Multiple sclerosis
  • Association
  • Susceptibility
  • Tumour Necrosis Factor
  • Autoinflammation


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