Abstract
Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5 x 10(-4), 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed.
Original language | English |
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Pages (from-to) | 110-112 |
Number of pages | 3 |
Journal | Journal of Neuroimmunology |
Volume | 235 |
Publication status | Published - Jun 2011 |
Keywords
- Multiple sclerosis
- Association
- Susceptibility
- Tumour Necrosis Factor
- Autoinflammation