Trait Interindividual Differences in the Effectiveness of Modafinil.

Jeroen Van Cutsem; Emilie Dessy; Martine Van Puyvelde; Olivier Mairesse; Royal Military Academy, Brussels Xavier Neyt; Nathalie Pattyn

doi:10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil.

Jeroen Van Cutsem, Emilie Dessy, Martine Van Puyvelde, Olivier Mairesse, Royal Military Academy, Brussels Xavier Neyt, Nathalie Pattyn

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research

2 Citations (Scopus)

Abstract

Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

Original language	English
Title of host publication	Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance
Editors	Pedro M. Arezes, Ronald L. Boring
Publisher	International Conference on Applied Human Factors and Ergonomics
Pages	12-20
Number of pages	9
ISBN (Print)	9783030802875
DOIs	https://doi.org/10.1007/978-3-030-80288-2_2
Publication status	Published - 2021

Publication series

Name	Lecture Notes in Networks and Systems
Volume	262 LNNS
ISSN (Print)	2367-3370
ISSN (Electronic)	2367-3389

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10.1007/978-3-030-80288-2_2

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Van Cutsem, J., Dessy, E., Van Puyvelde, M., Mairesse, O., Xavier Neyt, R. M. A. B., & Pattyn, N. (2021). Trait Interindividual Differences in the Effectiveness of Modafinil. In P. M. Arezes, & R. L. Boring (Eds.), Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance (pp. 12-20). (Lecture Notes in Networks and Systems; Vol. 262 LNNS). International Conference on Applied Human Factors and Ergonomics . https://doi.org/10.1007/978-3-030-80288-2_2

Van Cutsem, Jeroen ; Dessy, Emilie ; Van Puyvelde, Martine ; Mairesse, Olivier ; Xavier Neyt, Royal Military Academy, Brussels ; Pattyn, Nathalie. / Trait Interindividual Differences in the Effectiveness of Modafinil. Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance. editor / Pedro M. Arezes ; Ronald L. Boring. International Conference on Applied Human Factors and Ergonomics , 2021. pp. 12-20 (Lecture Notes in Networks and Systems).

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title = "Trait Interindividual Differences in the Effectiveness of Modafinil.",

abstract = "Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.",

author = "{Van Cutsem}, Jeroen and Emilie Dessy and {Van Puyvelde}, Martine and Olivier Mairesse and {Xavier Neyt}, {Royal Military Academy, Brussels} and Nathalie Pattyn",

year = "2021",

doi = "10.1007/978-3-030-80288-2_2",

language = "English",

isbn = "9783030802875",

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publisher = "International Conference on Applied Human Factors and Ergonomics ",

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Van Cutsem, J, Dessy, E, Van Puyvelde, M, Mairesse, O, Xavier Neyt, RMAB & Pattyn, N 2021, Trait Interindividual Differences in the Effectiveness of Modafinil. in PM Arezes & RL Boring (eds), Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance. Lecture Notes in Networks and Systems, vol. 262 LNNS, International Conference on Applied Human Factors and Ergonomics , pp. 12-20. https://doi.org/10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil. / Van Cutsem, Jeroen; Dessy, Emilie; Van Puyvelde, Martine; Mairesse, Olivier; Xavier Neyt, Royal Military Academy, Brussels; Pattyn, Nathalie.

Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance. ed. / Pedro M. Arezes; Ronald L. Boring. International Conference on Applied Human Factors and Ergonomics , 2021. p. 12-20 (Lecture Notes in Networks and Systems; Vol. 262 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research

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T1 - Trait Interindividual Differences in the Effectiveness of Modafinil.

AU - Van Cutsem, Jeroen

AU - Dessy, Emilie

AU - Van Puyvelde, Martine

AU - Mairesse, Olivier

AU - Xavier Neyt, Royal Military Academy, Brussels

AU - Pattyn, Nathalie

PY - 2021

Y1 - 2021

N2 - Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

AB - Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

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DO - 10.1007/978-3-030-80288-2_2

M3 - Conference paper

SN - 9783030802875

T3 - Lecture Notes in Networks and Systems

SP - 12

EP - 20

BT - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance

A2 - Arezes, Pedro M.

A2 - Boring, Ronald L.

PB - International Conference on Applied Human Factors and Ergonomics

ER -

Van Cutsem J, Dessy E, Van Puyvelde M, Mairesse O, Xavier Neyt RMAB, Pattyn N. Trait Interindividual Differences in the Effectiveness of Modafinil. In Arezes PM, Boring RL, editors, Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance. International Conference on Applied Human Factors and Ergonomics . 2021. p. 12-20. (Lecture Notes in Networks and Systems). https://doi.org/10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil.

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