Type and dose of gonadotropins in poor ovarian responders: does it matter?

Research output: Contribution to journalArticle


Infertile patients with a diminished ovarian reserve, also referred to as poor ovarian responders, constitute a substantial and increasing population of patients undergoing in vitro fertilization. The management of patients with poor ovarian response is still a controversial issue. Almost a century has passed since the introduction of the first gonadotropin. A broad collection of urinary and recombinant gonadotropins, including biosimilars, is commercially available now. Despite great advances in assisted reproductive technology, there remains uncertainty about the optimal treatment regimen for ovarian stimulation in poor ovarian responders. Although oocyte donation is the most successful and ultimate remedy for poor ovarian responders, most patients persist on using their own oocytes in several attempts, to achieve the desired pregnancy. The aim of this review is twofold: first, to provide an overview of the commercially available gonadotropins and summarize the available evidence supporting the use of one or another for ovarian stimulation in poor ovarian responders, and second, to address the controversies on the dosage of gonadotropins for this specific in vitro fertilization population.

Original languageEnglish
Article numberxx
Number of pages11
JournalTherapeutic advances in reproductive health
Publication statusPublished - 1 Jan 2021

Bibliographical note

© The Author(s), 2021.


  • gonadotropin dose
  • gonadotropins
  • ovarian stimulation
  • poor ovarian responder


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