Rationale: Liver disturbances are often observed in critically ill patients. Different etiologies are known including parenteral nutrition and drugs. The aim was to identify the 5 most used drugs with a potential hepatotoxic effect in the adult ICU.

Methods: Data on common used drugs in the period 1/1/2019 – 31/12/2019 in a 24-bed adult tertiary ICU in Brussels, Belgium were extracted from the pharmacy’s digital stock program. A list of medication with hepatotoxic profile was designed based on literature review. The use of parenteral nutrition in the same period was studied.

Results: 150.481 units of medication were listed and sorted by name and ranked by frequency of use.By comparison of both lists a top five of most frequently used hepatotoxic drugs was made: Paracetamol 1 gr intravenous (11.431 vials), amoxicillin-clavulanic acid 1gr IV (4.548 vials), flucloxacillin IV ( 1.028 vials), valproic acid IV (1.021 vials) and trimethoprim-sulfamethoxazole IV (571 vials). One thousand four hundred seventeen multi-chamber parenteral nutrition
bags were administered to the same ICU population in the same year.

Conclusion: Hepatotoxic medication and parenteral nutrition are extensively used in an adult tertiary ICU. This should be
considered in future research on Parenteral Nutrition Associated Liver Disease.
Original languageEnglish
Number of pages1
Publication statusPublished - 4 Sep 2022
EventESPEN Congress 2022 - Vienna, Austria
Duration: 3 Sep 20226 Sep 2022


ConferenceESPEN Congress 2022


  • parenteral nutrition
  • Intensive care unit
  • hepatotoxic
  • drugs


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