Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Sabine den Roover; Joeri L Aerts

doi:10.1016/j.omtn.2023.07.024

Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Sabine den Roover, Joeri L Aerts

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

38 Downloads (Pure)

Abstract

In order to unlock the full potential of gene therapy, understanding the cellular uptake mechanisms and choosing the most suitable delivery vehicle are crucially important. In the paper by Del Toro Runzer and colleagues recently published in Molecular Therapy – Nucleic Acids, the roles of the cellular uptake
mechanism, microenvironment, and cell type on the delivery of genetic materials
were extensively investigated (Figure 1).1 These insights could not only lead to
improved delivery but also to reduced cytotoxicity and beneficial therapeutic outcomes.

Original language	English
Pages (from-to)	545-547
Number of pages	3
Journal	Molecular Therapy Nucleic Acids
Volume	33
Early online date	10 Aug 2023
DOIs	https://doi.org/10.1016/j.omtn.2023.07.024
Publication status	Published - 12 Sept 2023

Bibliographical note

Publication history
Published online: August 10, 2023
Identification
DOI: https://doi.org/10.1016/j.omtn.2023.07.024

Copyright
© 2023 The Author(s).
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Keywords

COVID-19 Vaccines
mRNA
gene delivery
pDNA

Access to Document

10.1016/j.omtn.2023.07.024Licence: CC BY

1-s2.0-S216225312300197X-mainFinal published version, 1.77 MBLicence: CC BY

Cite this

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abstract = "In order to unlock the full potential of gene therapy, understanding the cellular uptake mechanisms and choosing the most suitable delivery vehicle are crucially important. In the paper by Del Toro Runzer and colleagues recently published in Molecular Therapy – Nucleic Acids, the roles of the cellular uptakemechanism, microenvironment, and cell type on the delivery of genetic materialswere extensively investigated (Figure 1).1 These insights could not only lead toimproved delivery but also to reduced cytotoxicity and beneficial therapeutic outcomes.",

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Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Abstract

Bibliographical note

Keywords

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FWOAL974: Development of a novel nanoparticle formulation for mRNA based therapeutic vaccination

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Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Projects

FWOAL974: Development of a novel nanoparticle formulation for mRNA based therapeutic vaccination

Cite this