Unveiling the intricacies of gene delivery: Caveolae-mediated endocytosis induces efficient mRNA delivery in slow-dividing cells

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Abstract

In order to unlock the full potential of gene therapy, understanding the cellular uptake mechanisms and choosing the most suitable delivery vehicle are crucially important. In the paper by Del Toro Runzer and colleagues recently published in Molecular Therapy – Nucleic Acids, the roles of the cellular uptake
mechanism, microenvironment, and cell type on the delivery of genetic materials
were extensively investigated (Figure 1).1 These insights could not only lead to
improved delivery but also to reduced cytotoxicity and beneficial therapeutic outcomes.
Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalMolecular Therapy Nucleic Acids
Volume33
Early online date10 Aug 2023
DOIs
Publication statusPublished - 12 Sep 2023

Bibliographical note

Publication history
Published online: August 10, 2023
Identification
DOI: https://doi.org/10.1016/j.omtn.2023.07.024

Copyright
© 2023 The Author(s).
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Keywords

  • COVID-19 Vaccines
  • mRNA
  • gene delivery
  • pDNA

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