Use of hyperglycemic clamp to assess a pancreatectomy and islet autotransplantation in a patient with dorsal pancreas agenesis and chronic pancreatitis

Research output: Unpublished contribution to conferencePoster

Abstract

BACKGROUND Patients with heterotaxy syndrome (HS) can present with an associated complete dorsal pancreas agenesis (DPA). They are considered to be at increased risk for the development of diabetes due to a reduced functional beta cell mass (FBM) as well as for chronic pancreatitis leading to untreatable pain. CASE DESCRIPTION We report the case of a patient that developed chronic pancreatitis due to HS and associated DPA. She presented to our center with severe abdominal pain refractory to non-surgical treatment. Unlike in previous reported cases, this patient had a high FBM (i.e. 150% of normoglycemic controls) determined by a hyperglycemic clamp. She was treated with total pancreatectomy followed by islet auto transplantation, leading to an adequate postoperative FBM (72% of normoglycemic controls) with preserved glycaemic control without need for exogenous insulin. After surgery, the pain disappeared, eliminating the need for opioid and other analgetics. CONCLUSIONS This case report shows that selected patients with HS and complete DPA can be considered for total pancreatectomy followed by islet autotransplantation in the presence of a sufficient FBM before surgery.
Original languageEnglish
Publication statusPublished - 2020
EventE-poster session presented at Virtual Belgian Surgical Week -
Duration: 25 Nov 202027 Nov 2020

Conference

ConferenceE-poster session presented at Virtual Belgian Surgical Week
Period25/11/2027/11/20

Fingerprint Dive into the research topics of 'Use of hyperglycemic clamp to assess a pancreatectomy and islet autotransplantation in a patient with dorsal pancreas agenesis and chronic pancreatitis'. Together they form a unique fingerprint.

Cite this