What are the best endpoints for Eczema Area and Severity Index and Scoring Atopic Dermatitis in clinical practice? A prospective observational study

Jonathan I Silverberg, Donald Lei, Sherief Janmohamed, Paras P Vakharia, Rishi Chopra, A. Chavda, Sherine Gabriel, Kiran Patel, Vivek Singam, Robert Kantor, Derek Y Hsu

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25 Citations (Scopus)
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Abstract

Background: Multiple strategies have been used to evaluate the minimal important change (MIC) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis (SCORAD). The meaningfulness of these MICs is not well established across all severities of atopic dermatitis (AD). Objectives: To determine the MIC of percentage and absolute improvement of EASI and SCORAD scores in adults and children with AD. Methods: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 826). An anchor-based approach was used to determine thresholds for the percentage and absolute MICs of EASI, SCORAD and objective SCORAD (O-SCORAD) at follow-up from baseline. Results: One-grade improvements of Physician's Global Assessment (PGA) and validated Investigator Global Assessment scale for AD (vIGA-AD) were associated with 50%, 35% and 35% decreases of EASI, SCORAD and O-SCORAD, respectively. The thresholds for percentage MIC of EASI (Kruskal-Wallis test, P = 0·61), SCORAD (P = 0·07) and O-SCORAD (P = 0·09) were similar across baseline AD severities. One-grade improvements of PGA and vIGA-AD were associated with 14·0- and 14·9-point decreases of EASI, 19·9- and 14·9-point decreases of SCORAD, and 15·5- and 17·4-point decreases of O-SCORAD. The thresholds for the absolute MIC of EASI (P < 0·001), SCORAD (P < 0·001) and O-SCORAD (P < 0·001) significantly differed by baseline AD severity. Percentage and absolute MICs for EASI and SCORAD were associated with improvements of AD symptoms and quality of life. Conclusions: EASI 50, SCORAD 35 and O-SCORAD 35 were meaningful percentage MICs regardless of baseline AD severity. The absolute MICs for EASI, SCORAD and O-SCORAD varied by baseline AD severity.
Original languageEnglish
Pages (from-to)888-895
Number of pages8
JournalBritish Journal of Dermatology
Volume184
Issue number5
Early online date5 Aug 2020
DOIs
Publication statusPublished - May 2021

Bibliographical note

Funding Information:
This publication was made possible with support from the Agency for Healthcare Research and Quality (AHRQ), grant number K12 HS023011, the Dermatology Foundation, and a research grant from Galderma. Northwestern Medicine Enterprise Data Warehouse (NMEDW) was supported, in part, by the Northwestern University Clinical and Translational Science Institute, funded, in part, by grant number UL1TR000150 from the National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Clinical and Translational Science Award (CTSA) is a registered trademark of DHHS.

Funding Information:
This publication was made possible with support from the Agency for Healthcare Research and Quality (AHRQ), grant number K12 HS023011, the Dermatology Foundation, and a research grant from Galderma. Northwestern Medicine Enterprise Data Warehouse (NMEDW) was supported, in part, by the Northwestern University Clinical and Translational Science Institute, funded, in part, by grant number UL1TR000150 from the National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Clinical and Translational Science Award (CTSA) is a registered trademark of DHHS.

Publisher Copyright:
© 2020 British Association of Dermatologists

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • EASI
  • SCORAD

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